Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition.
Journal
NPJ genomic medicine
ISSN: 2056-7944
Titre abrégé: NPJ Genom Med
Pays: England
ID NLM: 101685193
Informations de publication
Date de publication:
17 Mar 2021
17 Mar 2021
Historique:
received:
16
09
2020
accepted:
25
01
2021
entrez:
18
3
2021
pubmed:
19
3
2021
medline:
19
3
2021
Statut:
epublish
Résumé
Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors. The case emphasizes the beneficial role of molecular profiling in this target-poor disease.
Identifiants
pubmed: 33731690
doi: 10.1038/s41525-021-00186-9
pii: 10.1038/s41525-021-00186-9
pmc: PMC7969947
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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