The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders.
antigen presentation
autoimmunity
extracellular vesicle
immune-related adverse events
therapeutic delivery
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
05
2020
accepted:
04
01
2021
entrez:
18
3
2021
pubmed:
19
3
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Extracellular vesicles (EVs) are important players in autoimmune diseases, both in disease pathogenesis and as potential treatments. EVs can transport autoimmune triggers throughout the body, facilitating the process of antigen presentation. Understanding the link between cellular stress and EV biogenesis and intercellular trafficking will advance our understanding of autoimmune diseases. In addition, EVs can also be effective treatments for autoimmune diseases. The diversity of cell types that produce EVs leads to a wide range of molecules to be present in EVs, and thus EVs have a wide range of physiological effects. EVs derived from dendritic cells or mesenchymal stem cells have been shown to reduce inflammation. Since many autoimmune treatments are focused only on symptom management, EVs present a promising avenue for potential treatments. This review looks at the different roles EVs can play in autoimmune diseases, from disease pathology to diagnosis and treatment. We also overview various methodologies in isolating or generating EVs and look to the future for possible applications of EVs in autoimmune diseases.
Identifiants
pubmed: 33732229
doi: 10.3389/fimmu.2021.566299
pmc: PMC7959789
doi:
Substances chimiques
Autoantigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
566299Subventions
Organisme : NCI NIH HHS
ID : R01 CA230339
Pays : United States
Informations de copyright
Copyright © 2021 Lu, DiBernardo, Parks, Fox, Zheng and Wayne.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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