Salvianolic acid B protects against acute and chronic liver injury by inhibiting Smad2C/L phosphorylation.

liver injury nuclear factor erythroid-2-related factor 2/heme oxygenase-1 phosphorylated Smad2 at COOH-terminal/linker region salvianolic acid B

Journal

Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 03 05 2019
accepted: 19 03 2020
entrez: 18 3 2021
pubmed: 19 3 2021
medline: 19 3 2021
Statut: ppublish

Résumé

Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor β/Smad signaling pathway. However, how Sal B affects this antioxidant pathway and the phosphorylation (p-) of Smad2 at both the COOH-terminal (pSmad2C) and linker region (pSmad2L) are unknown. The aims of the present study were to investigate the underlying mechanisms of Sal B on acute and chronic liver injury induced by CCl

Identifiants

DOI: 10.3892/etm.2021.9772 PMID: 33732314 PMC: PMC7903446
pubmed: 33732314
doi: 10.3892/etm.2021.9772
pii: ETM-0-0-09772
pmc: PMC7903446
doi:

Types de publication

Journal Article

Langues

eng

Pagination

341

Informations de copyright

Copyright: © Tao et al.

Déclaration de conflit d'intérêts

The authors declare that they have no competing interests.

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Auteurs

Xiang-Ming Tao (XM)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Dong Li (D)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Chong Zhang (C)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Guang-Hua Wen (GH)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Chao Wu (C)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Yuan-Yuan Xu (YY)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Yue Kan (Y)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Wan-Peng Lu (WP)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Han-Yan Ding (HY)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Yan Yang (Y)

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, P.R. China.

Classifications MeSH