AMIGO2 as a novel indicator of liver metastasis in patients with colorectal cancer.
AMIGO2
CRC
liver metastasis
recurrence
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
11
03
2020
accepted:
10
11
2020
entrez:
18
3
2021
pubmed:
19
3
2021
medline:
19
3
2021
Statut:
ppublish
Résumé
Our previous study showed that adhesion molecule with immunoglobulin like domain 2 (AMIGO2) is a pivotal driver gene of liver metastasis via regulating tumor cell adhesion to liver endothelial cells in mouse models. The aim of the present study was to clarify the role of AMIGO2 in liver metastasis in patients the colorectal cancer (CRC). Two human CRC cell lines, Caco-2 (AMIGO2-low) and HCT116 (AMIGO2-high), were used in this study. AMIGO2-overexpressing Caco-2 and AMIGO2-knockdown HCT116 cells were generated by transfection with an AMIGO2 expression vector or AMIGO2 small interfering RNA, respectively. Cell proliferation, invasion and adhesion to human liver endothelial cells were examined in
Identifiants
pubmed: 33732354
doi: 10.3892/ol.2021.12539
pii: OL-0-0-12539
pmc: PMC7905583
doi:
Types de publication
Journal Article
Langues
eng
Pagination
278Informations de copyright
Copyright: © Tanio et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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