Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction
Angiotensin-converting enzyme 2
Clioquinol
Coronavirus disease 2019
Receptor binding domain
Severe acute respiratory syndrome coronavirus 2
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
06
12
2020
revised:
05
02
2021
accepted:
02
05
2021
entrez:
18
3
2021
pubmed:
19
3
2021
medline:
19
3
2021
Statut:
ppublish
Résumé
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. Herein, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a Food and Drug Administration (FDA) approved drug, and two of its analogues (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ14); and 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) as potent inhibitors of SARS-CoV-2 infection-induced cytopathic effect
Identifiants
pubmed: 33732940
doi: 10.1016/j.heliyon.2021.e06426
pii: S2405-8440(21)00531-4
pmc: PMC7951571
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e06426Subventions
Organisme : NIMHD NIH HHS
ID : U54 MD007605
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Psychopharmacology (Berl). 2021 Feb;238(2):329-340
pubmed: 33410987
Cancer Lett. 2008 Nov 28;271(2):251-9
pubmed: 18639975
Proc Natl Acad Sci U S A. 1974 May;71(5):2091-5
pubmed: 4134617
Virus Res. 2015 Apr 16;202:120-34
pubmed: 25445340
Neuron. 2008 Jul 10;59(1):43-55
pubmed: 18614028
Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):236-246
pubmed: 29481714
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8374-9
pubmed: 19416844
Cell. 2020 May 14;181(4):894-904.e9
pubmed: 32275855
Parasite. 2020;27:29
pubmed: 32351209
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
JALA Charlottesv Va. 2008 Jun;13(3):168-173
pubmed: 19492073
EClinicalMedicine. 2020 Aug;25:100464
pubmed: 32838237
FEBS Lett. 2002 Dec 4;532(1-2):107-10
pubmed: 12459472
Cell Res. 2017 Jan;27(1):119-129
pubmed: 28008928
Aging (Albany NY). 2020 May 18;12(10):9515-9533
pubmed: 32424108
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Lancet Neurol. 2008 Sep;7(9):779-86
pubmed: 18672400
mBio. 2018 Dec 11;9(6):
pubmed: 30538186
J Mycol Med. 2018 Sep;28(3):492-501
pubmed: 29650464
Neurotherapeutics. 2015 Jan;12(1):109-20
pubmed: 25354461
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Transl Res. 2009 Sep;154(3):153-9
pubmed: 19665691
J Infect Dis. 1983 Sep;148(3):613
pubmed: 6225809
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Biochem J. 2009 Jan 1;417(1):133-9
pubmed: 18764784
Toxicol Lett. 2008 Nov 10;182(1-3):1-6
pubmed: 18812216
J Virol. 2015 Feb;89(4):1954-64
pubmed: 25428871
Cardiovasc Toxicol. 2017 Oct;17(4):434-440
pubmed: 28213753
EMBO J. 2005 Apr 20;24(8):1634-43
pubmed: 15791205
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5871-6
pubmed: 19321428
Nature. 2016 Mar 3;531(7592):118-21
pubmed: 26935699
J Biol Chem. 2002 Apr 26;277(17):14838-43
pubmed: 11815627
Clin Lymphoma Myeloma Leuk. 2012 Oct;12(5):330-6
pubmed: 22683301
Arch Neurol. 2003 Dec;60(12):1685-91
pubmed: 14676042
J Virol. 2009 Aug;83(15):7411-21
pubmed: 19439480
JAMA. 2020 May 26;323(20):1999
pubmed: 32453363
Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1084-H1090
pubmed: 32228252
J Am Coll Cardiol. 2020 May 26;75(20):2623-2624
pubmed: 32283123
Curr Opin Chem Biol. 2000 Apr;4(2):162-5
pubmed: 10742185
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Biomed J. 2020 Oct;43(5):424-433
pubmed: 32792167
Nat Rev Microbiol. 2018 Jun;16(6):341-354
pubmed: 29556036
Jpn J Med Sci Biol. 1971 Aug;24(4):195-216
pubmed: 4944758
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
Am J Physiol Cell Physiol. 2008 Mar;294(3):C726-42
pubmed: 18184873
J Gen Virol. 2008 Nov;89(Pt 11):2741-2745
pubmed: 18931070
PLoS One. 2009 Nov 17;4(11):e7870
pubmed: 19924243
Exp Gerontol. 2008 May;43(5):394-408
pubmed: 18221847
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Nat Med. 2009 Apr;15(4):356-9
pubmed: 19350001
Science. 2005 Sep 16;309(5742):1864-8
pubmed: 16166518
Lett Pept Sci. 2003;10(5):377-385
pubmed: 32214681
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
J Biol Chem. 2004 Apr 23;279(17):17996-8007
pubmed: 14754895
JAMA Cardiol. 2020 Jul 1;5(7):831-840
pubmed: 32219363
JAMA. 2020 May 12;323(18):1824-1836
pubmed: 32282022
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
Heart Rhythm. 2015 Oct;12(10):2186-94
pubmed: 26025323
PLoS Pathog. 2018 Aug 13;14(8):e1007236
pubmed: 30102747
Br J Prev Soc Med. 1975 Sep;29(3):157-69
pubmed: 127638
Pharmacol Ther. 2019 Jul;199:155-163
pubmed: 30898518
J Antimicrob Chemother. 2010 Jul;65(7):1424-7
pubmed: 20435781
J Biomol Screen. 2007 Feb;12(1):33-40
pubmed: 17200104
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
J Huntingtons Dis. 2012;1(2):211-9
pubmed: 25063332
Tuberculosis (Edinb). 2011 Dec;91 Suppl 1:S61-5
pubmed: 22115541
Cancer Res. 2005 Apr 15;65(8):3389-95
pubmed: 15833873
EMBO J. 2003 Jan 2;22(1):13-23
pubmed: 12505980
Pharm Res. 2018 Mar 5;35(4):83
pubmed: 29508078
Biochim Biophys Acta. 2000 Mar 7;1477(1-2):157-67
pubmed: 10708856
Nat Rev Cardiol. 2020 Sep;17(9):543-558
pubmed: 32690910