Valproate is associated with early decrease of high-density lipoprotein cholesterol levels in the psychiatric population.
anticonvulsants
dyslipidaemia
epilepsia
obesity
psychopharmacology
Journal
Basic & clinical pharmacology & toxicology
ISSN: 1742-7843
Titre abrégé: Basic Clin Pharmacol Toxicol
Pays: England
ID NLM: 101208422
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
08
02
2021
received:
24
09
2020
accepted:
09
03
2021
pubmed:
19
3
2021
medline:
15
12
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
Few studies have evaluated the influence of valproate on the deterioration of the lipid profile in psychiatric patients. This observational study aimed to compare the evolution of metabolic parameters in a sample of adult patients starting valproate (n = 39) with a control group (n = 39) of patients starting aripiprazole, a drug associated with a low risk of metabolic deterioration. Data were obtained from a prospective study including psychiatric patients with metabolic parameters monitored during the first year of treatment. During the first month of treatment with valproate (median: 31 days [IQR: 25-36]), mean body mass index increased significantly (from 24.8 kg/m
Substances chimiques
Cholesterol, HDL
0
Valproic Acid
614OI1Z5WI
Aripiprazole
82VFR53I78
Types de publication
Comparative Study
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-35Subventions
Organisme : Swiss National Research Foundation
ID : 320030-120686
Organisme : Swiss National Research Foundation
ID : 320030-173211
Organisme : Swiss National Research Foundation
ID : 324730-144064
Informations de copyright
© 2021 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
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