ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1.
Asthma
Pu.1 protein
V-type ATPase
alveolar macrophage
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
18
05
2020
revised:
20
07
2020
accepted:
07
09
2020
entrez:
18
3
2021
pubmed:
19
3
2021
medline:
19
3
2021
Statut:
ppublish
Résumé
Macrophages are important regulators of environmental allergen-induced airway inflammation and asthma. ATP6V0d2 is a subunit of vacuolar ATPase highly expressed in macrophages. However, the functions of ATP6V0d2 in the regulation of pathogenesis of allergic asthma remain unclear. The aim of this study is to determine the function and related molecular mechanisms of macrophage protein ATP6V0d2 in allergic asthma. We compared the disease severity between female C57BL/6 wild-type and The expression of Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.
Identifiants
pubmed: 33733641
pii: 13.479
doi: 10.4168/aair.2021.13.3.479
pmc: PMC7984956
doi:
Types de publication
Journal Article
Langues
eng
Pagination
479-497Subventions
Organisme : Ministry of Science and Technology of the People's Republic of China
ID : 2019YFC1316203
Pays : China
Organisme : National Natural Science Foundation of China
ID : 81671539
Pays : China
Organisme : National Natural Science Foundation of China
ID : 31870892
Pays : China
Organisme : National Natural Science Foundation of China
ID : 81725004
Pays : China
Organisme : National Natural Science Foundation of China
ID : 81670019
Pays : China
Organisme : National Natural Science Foundation of China
ID : 91742108
Pays : China
Informations de copyright
Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
There are no financial or other issues that might lead to conflict of interest.
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