Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell lymphocytosis, and small lymphocytic lymphoma.
Flow cytometry
antibody binding capacity
antigen quantitation
chronic lymphocytic leukemia
mean fluorescence intensity
prognosis
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
19
3
2021
medline:
17
8
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
We demonstrate the prognostic utility of antigen quantitation in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis (MBL). Median antibody-bound-per-cell (ABC) of CD20, CD22, CD25, CD19, and %CD38(+) was determined in CLL (185/208), SLL (8/208) and MBL (15/208) cases by flow cytometry, then compared to Dohner-classification, immunoglobulin status (mutated, IGHV-M; unmutated, IGHV-U), CLL-IPI risk and time to first treatment (TTFT). Trisomy 12 cases showed increased %CD38-expression (
Identifiants
pubmed: 33734005
doi: 10.1080/10428194.2021.1894641
pmc: PMC9464423
mid: NIHMS1833608
doi:
Substances chimiques
Immunoglobulin Heavy Chains
0
Banques de données
ClinicalTrials.gov
['NCT00001620']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1828-1839Subventions
Organisme : Intramural NIH HHS
ID : ZIA HL006070
Pays : United States
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