Mapping default mode connectivity alterations following a single season of subconcussive impact exposure in youth football.
concussion
connectivity
fMRI
football
subconcussion
youth
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
revised:
09
02
2021
received:
26
06
2020
accepted:
10
02
2021
pubmed:
19
3
2021
medline:
25
3
2022
entrez:
18
3
2021
Statut:
ppublish
Résumé
Repetitive head impact (RHI) exposure in collision sports may contribute to adverse neurological outcomes in former players. In contrast to a concussion, or mild traumatic brain injury, "subconcussive" RHIs represent a more frequent and asymptomatic form of exposure. The neural network-level signatures characterizing subconcussive RHIs in youth collision-sport cohorts such as American Football are not known. Here, we used resting-state functional MRI to examine default mode network (DMN) functional connectivity (FC) following a single football season in youth players (n = 50, ages 8-14) without concussion. Football players demonstrated reduced FC across widespread DMN regions compared with non-collision sport controls at postseason but not preseason. In a subsample from the original cohort (n = 17), players revealed a negative change in FC between preseason and postseason and a positive and compensatory change in FC during the offseason across the majority of DMN regions. Lastly, significant FC changes, including between preseason and postseason and between in- and off-season, were specific to players at the upper end of the head impact frequency distribution. These findings represent initial evidence of network-level FC abnormalities following repetitive, non-concussive RHIs in youth football. Furthermore, the number of subconcussive RHIs proved to be a key factor influencing DMN FC.
Identifiants
pubmed: 33734521
doi: 10.1002/hbm.25384
pmc: PMC8090779
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2529-2545Subventions
Organisme : NINDS NIH HHS
ID : R01 NS082453
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091602
Pays : United States
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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