Aryl hydrocarbon receptor (Ahr)-dependent Il-22 expression by type 3 innate lymphoid cells control of acute joint inflammation.
Acute Disease
Animals
Arthritis, Experimental
/ etiology
Basic Helix-Loop-Helix Transcription Factors
/ physiology
Female
Immunity, Innate
/ immunology
Inflammation
/ etiology
Interleukins
/ physiology
Joints
/ metabolism
Lymphocytes
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Aryl Hydrocarbon
/ physiology
Interleukin-22
IL-22
acute arthritis
aryl hydrocarbon receptor
inflammation
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
16
02
2021
received:
03
11
2020
accepted:
20
02
2021
pubmed:
19
3
2021
medline:
5
10
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
The aryl hydrocarbon receptor (AHR) controls several inflammatory and metabolic pathways involved in various diseases, including the development of arthritis. Here, we investigated the role of AHR activation in IL-22-dependent acute arthritis using the K/BxN serum transfer model. We observed an overall reduction of cytokine expression in Ahr-deficient mice, along with decreased signs of joint inflammation. Conversely, we report worsened arthritis symptoms in Il-22 deficient mice. Pharmacological stimulation of AHR with the agonist VAG539, as well as injection of recombinant IL-22, given prior arthritogenic triggering, attenuated inflammation and reduced joint destruction. The protective effect of VAG539 was abrogated in Il-22 deficient mice. Finally, conditional Ahr depletion of Rorc-expressing cells was sufficient to attenuate arthritis, thereby uncovering a previously unsuspected role of AHR in type 3 innate lymphoid cells during acute arthritis.
Identifiants
pubmed: 33734594
doi: 10.1111/jcmm.16433
pmc: PMC8107095
doi:
Substances chimiques
Ahr protein, mouse
0
Basic Helix-Loop-Helix Transcription Factors
0
Interleukins
0
Receptors, Aryl Hydrocarbon
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4721-4731Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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