Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study.
analgesic effect
cancer therapy
indomethacin spray
oral mucositis pain
quality of life
Journal
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
ISSN: 1754-4505
Titre abrégé: Spec Care Dentist
Pays: United States
ID NLM: 8103755
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
02
03
2021
received:
31
12
2020
accepted:
04
03
2021
pubmed:
19
3
2021
medline:
7
7
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
Symptomatic treatment is insufficient for chemotherapy- or targeted therapy-induced oral mucositis (OM) pain, and benzydamine mouthwash is not commercially available in Japan. We evaluated the analgesic effects of an in-hospital preparation of 0.25% indomethacin spray (IMS) on anticancer drug-induced OM pain. This single-arm prospective trial enrolled 20 patients (median age 62.0 years) with OM and numerical rating scale scores of ≥5 who were undergoing chemotherapy or targeted therapy in our hospital. Pain scores were recorded using a visual analog scale (VAS) before and 30 min after IMS administration. Pain relief (PR) scores were recorded at 15, 30, and 60 min after IMS administration; total PR after 60 min (TOTPAR The median (interquartile range) OM grade of the participants was 2.0 (2.0-2.3). The VAS score decreased significantly at 30 min after IMS administration (p = .001). The median (interquartile range) TOTPAR IMS helped improve patients' quality of life. The risk of systemic adverse effects was low because of the low dose administered. IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication.
Identifiants
pubmed: 33735535
doi: 10.1111/scd.12587
pmc: PMC8360043
doi:
Substances chimiques
Analgesics
0
Pharmaceutical Preparations
0
Indomethacin
XXE1CET956
Types de publication
Clinical Trial
Journal Article
Langues
eng
Pagination
498-504Informations de copyright
© 2021 The Authors. Special Care in Dentistry published by Special Care Dentistry Association and Wiley Periodicals LLC.
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