Rethinking phage-bacteria-eukaryotic relationships and their influence on human health.
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
12 05 2021
12 05 2021
Historique:
received:
29
11
2020
revised:
19
01
2021
accepted:
09
02
2021
pubmed:
19
3
2021
medline:
21
10
2021
entrez:
18
3
2021
Statut:
ppublish
Résumé
There is a rapidly growing body of research demonstrating the unique and often surprising mechanisms by which bacteriophages, specialized viruses of bacteria, can influence human health and disease states. This can occur directly by shaping their bacterial host's ecology through top-down pressure or via more indirect routes, including influencing the human body's metabolism or immune system. These microbial interactions can affect health and disease states in both the local environment or by influencing the body's distal organs or systems. Here we provide an update on the current understanding of bacteriophages' influence on human health within the context of tripartite symbioses with their bacterial and human hosts.
Identifiants
pubmed: 33735620
pii: S1931-3128(21)00086-X
doi: 10.1016/j.chom.2021.02.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
681-688Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests Jeremy J. Barr is a member of the Centre to Impact AMR, Monash University, Clayton, Victoria, Australia.