Hypoglycemia in mitochondrial disorders.

Blood Glucose / metabolism Cohort Studies Female Humans Hypoglycemia / complications Male Mitochondrial Diseases / complications
Glucose level Hyperglycemia Hypoglycemia Mitochondrial disorder

Journal

Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751

Informations de publication

Date de publication:
05 2021
Historique:
received: 18 09 2020
revised: 23 12 2020
accepted: 08 03 2021
pubmed: 20 3 2021
medline: 15 1 2022
entrez: 19 3 2021
Statut: ppublish

Résumé

Diabetes and hyperglycemia are common features of mitochondrial disorders. This study investigates the frequency of non-iatrogenic hypoglycemia in individuals with these disorders. Of 116 patients, 22 (18.97%) experienced at least two episodes of hypoglycemia. This rate is significantly higher (p < 0.05) than the 6% seen in the non-diabetic, general population. Neonatal readings were 30 mg/dL lower than non-neonatal readings. As hypoglycemia appears to occur frequently in individuals with mitochondrial disorders, with lower blood glucose levels in the neonatal period, early and continued monitoring of blood glucose is necessary. Also, mitochondrial disorders should be considered in cases of recurrent hypoglycemia.

Identifiants

DOI: 10.1016/j.mito.2021.03.002 PMID: 33737013
pubmed: 33737013
pii: S1567-7249(21)00034-9
doi: 10.1016/j.mito.2021.03.002
pii:
doi:

Substances chimiques

Blood Glucose 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

179-183

Informations de copyright

Published by Elsevier B.V.

Auteurs

Myla Ashfaq (M)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

Allison R Moats (AR)

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

Hope Northrup (H)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

Claire N Singletary (CN)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.

S Shahrukh Hashmi (SS)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Pediatrics, Pediatric Research Center, McGovern Medical School at The University of Texas Health Center at Houston, Houston, TX, USA.

Mary Kay Koenig (MK)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.

Michael B Bagg (MB)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.

David Rodriguez-Buritica (D)

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pediatrics, Division of Medical Genetics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: David.F.RodriguezBuritica@uth.tmc.edu.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Hypoglycemia in mitochondrial disorders.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Hypoglycemia in mitochondrial disorders.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hypoglycemia in mitochondrial disorders.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hypoglycémie › Hypoglycemia in mitochondrial disorders.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies mitochondriales › Hypoglycemia in mitochondrial disorders.