Serum amyloid A concentrations, COVID-19 severity and mortality: An updated systematic review and meta-analysis.

Aspartate Aminotransferases COVID-19 / blood Humans SARS-CoV-2 Serum Amyloid A Protein / metabolism Severity of Illness Index
COVID-19 Disease severity Mortality Serum amyloid A

Journal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 19 01 2021
revised: 01 03 2021
accepted: 10 03 2021
pubmed: 20 3 2021
medline: 25 5 2021
entrez: 19 3 2021
Statut: ppublish

Résumé

An excessive inflammatory response in patients with coronavirus disease 2019 (COVID-19) is associated with high disease severity and mortality. Specific acute phase reactants might be useful for risk stratification. A systematic review and meta-analysis was conducted of studies on serum amyloid A (SAA) in patients with COVID-19. The PubMed, Web of Science, and Scopus databases were searched, covering the period January 2020 to December 2020, for studies reporting SAA concentrations, COVID-19 severity, and survival status. Nineteen studies involving 5617 COVID-19 patients were included in the meta-analysis. Pooled results showed that SAA concentrations were significantly higher in patients with severe disease and non-survivors (standard mean difference (SMD) 1.20, 95% confidence interval 0.91-1.49, P < 0.001). Extreme between-study heterogeneity was observed (I SAA concentrations were significantly and positively associated with higher COVID-19 severity and mortality. This acute phase reactant might assist with risk stratification and monitoring in this group.

Sections du résumé

BACKGROUND AND OBJECTIVES OBJECTIVE
An excessive inflammatory response in patients with coronavirus disease 2019 (COVID-19) is associated with high disease severity and mortality. Specific acute phase reactants might be useful for risk stratification. A systematic review and meta-analysis was conducted of studies on serum amyloid A (SAA) in patients with COVID-19.
METHODS METHODS
The PubMed, Web of Science, and Scopus databases were searched, covering the period January 2020 to December 2020, for studies reporting SAA concentrations, COVID-19 severity, and survival status.
RESULTS RESULTS
Nineteen studies involving 5617 COVID-19 patients were included in the meta-analysis. Pooled results showed that SAA concentrations were significantly higher in patients with severe disease and non-survivors (standard mean difference (SMD) 1.20, 95% confidence interval 0.91-1.49, P < 0.001). Extreme between-study heterogeneity was observed (I
CONCLUSIONS CONCLUSIONS
SAA concentrations were significantly and positively associated with higher COVID-19 severity and mortality. This acute phase reactant might assist with risk stratification and monitoring in this group.

Identifiants

DOI: 10.1016/j.ijid.2021.03.025 PMID: 33737133 PMC: PMC7959678
pubmed: 33737133
pii: S1201-9712(21)00243-5
doi: 10.1016/j.ijid.2021.03.025
pmc: PMC7959678
pii:
doi:

Substances chimiques

Serum Amyloid A Protein 0
Aspartate Aminotransferases EC 2.6.1.1

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

668-674

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Angelo Zinellu (A)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Panagiotis Paliogiannis (P)

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Ciriaco Carru (C)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy; Quality Control Unit, University Hospital (AOUSS), Sassari, Italy.

Arduino A Mangoni (AA)

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia. Electronic address: arduino.mangoni@flinders.edu.au.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Serum amyloid A concentrations, COVID-19...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Serum amyloid A concentrations, COVID-19...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Protéine de la phase aigüe › Protéine amyloïde A sérique › Serum amyloid A concentrations, COVID-19...
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