γδ T cells regulate the intestinal response to nutrient sensing.
Adaptation, Physiological
Animals
Cell Communication
Dietary Carbohydrates
/ administration & dosage
Dietary Proteins
/ administration & dosage
Digestion
Enterocytes
/ physiology
Gene Expression Regulation
Interleukins
/ genetics
Intestinal Absorption
Intestinal Mucosa
/ cytology
Intestine, Small
/ cytology
Mice, Inbred C57BL
Nutrients
/ administration & dosage
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocyte Subsets
/ immunology
Transcription, Genetic
Transcriptome
Interleukin-22
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
19 03 2021
19 03 2021
Historique:
received:
08
01
2020
revised:
02
11
2020
accepted:
19
01
2021
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
27
3
2021
Statut:
ppublish
Résumé
The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The "on-demand" induction of this machinery required γδ T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of γδ T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for γδ T cells in nutrient sensing.
Identifiants
pubmed: 33737460
pii: 371/6535/eaba8310
doi: 10.1126/science.aba8310
pii:
doi:
Substances chimiques
Dietary Carbohydrates
0
Dietary Proteins
0
Interleukins
0
Receptors, Antigen, T-Cell, gamma-delta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : K08 AI128745
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : F32 AI143141
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK125089
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.