Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function.
Adolescent
Adult
Cardiovascular Diseases
/ diagnostic imaging
Child
Child, Preschool
Echocardiography
/ methods
Female
Follow-Up Studies
Frailty
/ epidemiology
Health Status
Heart
/ anatomy & histology
Humans
Infant
Infant, Newborn
Life Style
Longitudinal Studies
Male
Middle Aged
Myocardial Contraction
Organ Size
Risk Factors
Stroke Volume
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 03 2021
18 03 2021
Historique:
received:
13
11
2020
accepted:
25
01
2021
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
28
10
2021
Statut:
epublish
Résumé
A frailty index (FI) counts health deficit accumulation. Besides traditional risk factors, it is unknown whether the health deficit burden is related to the appearance of cardiovascular disease. In order to answer this question, the same multidimensional FI looking at 45-health deficits was serially calculated per participant at 4 time periods (0-16, 19-44, 45-54 and 60-64 years) using data from the 1946 Medical Research Council (MRC) British National Survey of Health and Development (NSHD)-the world's longest running longitudinal birth cohort with continuous follow-up. From these the mean and total FI for the life-course, and the step change in deficit accumulation from one time period to another was derived. Echocardiographic data at 60-64 years provided: ejection fraction (EF), left ventricular mass indexed to body surface area (LVmassi, BSA), myocardial contraction fraction indexed to BSA (MCF
Identifiants
pubmed: 33737563
doi: 10.1038/s41598-021-85435-8
pii: 10.1038/s41598-021-85435-8
pmc: PMC7973558
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6272Subventions
Organisme : British Heart Foundation
ID : SP/20/2/34841
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12019/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12019/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12019/4
Pays : United Kingdom
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