Translational Research in Vitiligo.

Animals Autoimmunity Dermatologic Agents / therapeutic use Disease Models, Animal Genetic Testing Humans Melanocytes / drug effects Oxidative Stress Phenotype Skin / drug effects Skin Pigmentation / drug effects Translational Research, Biomedical Vitiligo / drug therapy
autoimmunity genetics melanocyte oxidative stress translational research vitiligo

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 31 10 2020
accepted: 14 01 2021
entrez: 19 3 2021
pubmed: 20 3 2021
medline: 15 9 2021
Statut: epublish

Résumé

Vitiligo is a disease of the skin characterized by the appearance of white spots. Significant progress has been made in understanding vitiligo pathogenesis over the past 30 years, but only through perseverance, collaboration, and open-minded discussion. Early hypotheses considered roles for innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics. Because theories about pathogenesis drive experimental design, focus, and even therapeutic approach, it is important to consider their impact on our current understanding about vitiligo. Animal models allow researchers to perform mechanistic studies, and the development of improved patient sample collection methods provides a platform for translational studies in vitiligo that can also be applied to understand other autoimmune diseases that are more difficult to study in human samples. Here we discuss the history of vitiligo translational research, recent advances, and their implications for new treatment approaches.

Identifiants

DOI: 10.3389/fimmu.2021.624517 PMID: 33737930 PMC: PMC7962476
pubmed: 33737930
doi: 10.3389/fimmu.2021.624517
pmc: PMC7962476
doi:

Substances chimiques

Dermatologic Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

624517

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR069114
Pays : United States
Organisme : NIAMS NIH HHS
ID : R61 AR073042
Pays : United States
Organisme : NIAMS NIH HHS
ID : R33 AR073042
Pays : United States

Informations de copyright

Copyright © 2021 Katz and Harris.

Déclaration de conflit d'intérêts

JEH is a consultant for Pfizer, Genzyme/Sanofi, Aclaris Therapeutics Inc, Incyte, Rheos Medicines, Sun Pharmaceuticals, LEO Pharma, Villaris Therapeutics Inc, Dermavant, Temprian, AbbVie Inc, Janssen, TeVido BioDevices, EMD Serono, Almirall, Boston Pharma, Sonoma Biotherapeutics Inc, Methuselah Health, Twi Biotech, Pandion, Cogen Therapeutics Inc, Admirx, BridgeBio, AnaptysBio, Avita, and Frazier Management. JEH is an investigator for Pfizer, Genzyme/Sanofi, Aclaris Therapeutics Inc, Incyte, Rheos Medicines, Sun Pharmaceuticals, LEO Pharma, Villaris Therapeutics Inc, Dermavant, AbbVie, TeVido BioDevices, EMD Serono, and Pandion. JEH is scientific founder of Villaris Therapeutics, Inc, which develops therapeutic treatments for vitiligo, and NIRA Biosciences. JEH is an inventor on patent #62489191 “Diagnosis and Treatment of Vitiligo” that includes targeting IL-15 and Trm for treatment of vitiligo, as well as #067988 “Anti-Human CXCR3 Antibodies for Treatment of Vitiligo” and #029531 “Compositions and Methods for Treating Vitiligo”. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Erica L Katz (EL)

Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.

John E Harris (JE)

Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Translational Research in Vitiligo.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Translational Research in Vitiligo.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Produits dermatologiques › Translational Research in Vitiligo.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Translational Research in Vitiligo.
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Translational Research in Vitiligo.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Translational Research in Vitiligo.
questionsmedicales.fr › Cellules › Cellules épithéliales › Mélanocytes › Translational Research in Vitiligo.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Translational Research in Vitiligo.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Translational Research in Vitiligo.
questionsmedicales.fr › Système tégumentaire › Peau › Translational Research in Vitiligo.
questionsmedicales.fr › Phénomènes biologiques › Pigmentation › Pigmentation de la peau › Translational Research in Vitiligo.
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Recherche médicale translationnelle › Translational Research in Vitiligo.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Hypopigmentation › Vitiligo › Translational Research in Vitiligo.