Molecular biological findings of ameloblastoma.

Ameloblastoma Biology Review

Journal

The Japanese dental science review
ISSN: 1882-7616
Titre abrégé: Jpn Dent Sci Rev
Pays: Netherlands
ID NLM: 101481371

Informations de publication

Date de publication:
Nov 2021
Historique:
received: 28 05 2020
revised: 17 11 2020
accepted: 13 12 2020
entrez: 19 3 2021
pubmed: 20 3 2021
medline: 20 3 2021
Statut: ppublish

Résumé

Ameloblastoma is benign odontogenic tumours that mainly occur in the jawbone. This tumour induces aggressive invasion into the surrounding bone and has a high recurrence rate after surgery. Therefore, mandibular resection is performed in many patients with this tumour, causing aesthetic and functional problems. It is necessary to develop a novel treatment strategy for ameloblastoma, but there are currently no innovative treatments. Although our understanding of the molecular biological mechanisms of ameloblastoma is still insufficient, there have been many recent reports of new molecular biological findings on ameloblastoma. Therefore, bioactive factors that have potential for novel therapeutic methods, such as molecular targeted therapy, have been discovered in ameloblastoma. In this review, we summarize the molecular biological findings of ameloblastoma reported over several decades, focusing on factors involved in invasion into surrounding tissues and disease-specific gene mutations. We also mention the effect of the interaction between tumour cells and stromal components in ameloblastoma on tumour development.

Identifiants

pubmed: 33737992
doi: 10.1016/j.jdsr.2020.12.003
pii: S1882-7616(21)00004-1
pmc: PMC7946346
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

27-32

Informations de copyright

© 2021 The Authors.

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Auteurs

Takao Fuchigami (T)

Department of Oral and Maxillofacial Surgery, Field of Maxillofacial Rehabilitation Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Yusuke Ono (Y)

Department of Oral and Maxillofacial Surgery, Field of Maxillofacial Rehabilitation Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Shosei Kishida (S)

Department of Biochemistry and Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Norifumi Nakamura (N)

Department of Oral and Maxillofacial Surgery, Field of Maxillofacial Rehabilitation Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Classifications MeSH