Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
13
07
2020
accepted:
03
02
2021
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
20
3
2021
Statut:
epublish
Résumé
Furin plays an important role in various pathological states, especially in bacterial and viral infections. A detailed understanding of the structural requirements for inhibitors targeting this enzyme is crucial to develop new therapeutic strategies in infectious diseases, including an urgent unmet need for SARS-CoV-2 infection. Previously, we have identified a potent furin inhibitor, peptide Ac-RARRRKKRT-
Identifiants
pubmed: 33738063
doi: 10.1021/acsmedchemlett.0c00386
pmc: PMC7957945
doi:
Types de publication
Journal Article
Langues
eng
Pagination
365-372Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): Robert Day is a stakeholder in Phenoswitch Bioscience Inc.
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