Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
06
01
2021
accepted:
24
02
2021
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
20
3
2021
Statut:
epublish
Résumé
Protein N-terminal methyltransferases (NTMTs) catalyze the methylation of the α-N-terminal amines of proteins starting with an X-P-K/R motif. NTMT1 has been implicated in various cancers and in aging, implying its role as a potential therapeutic target. Through structural modifications of a lead NTMT1 inhibitor,
Identifiants
pubmed: 33738076
doi: 10.1021/acsmedchemlett.1c00012
pmc: PMC7958150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
485-493Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM117275
Pays : United States
Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Chembiochem. 2019 Apr 15;20(8):976-984
pubmed: 30479015
Biochem J. 2013 Dec 15;456(3):453-62
pubmed: 24090352
Nat Commun. 2017 Mar 07;8:14678
pubmed: 28266506
Nat Cell Biol. 2007 May;9(5):596-603
pubmed: 17435751
J Proteome Res. 2015 Jun 5;14(6):2575-82
pubmed: 25886813
J Proteome Res. 2013 Sep 6;12(9):4167-75
pubmed: 23978223
J Med Chem. 2020 Sep 10;63(17):9512-9522
pubmed: 32689795
J Med Chem. 2020 Aug 13;63(15):8419-8431
pubmed: 32605369
FEBS Lett. 1976 Sep 15;68(1):115-8
pubmed: 786732
Oncotarget. 2015 May 20;6(14):12248-63
pubmed: 25909287
RSC Adv. 2016;6(8):6768-6771
pubmed: 27588169
J Biol Chem. 2015 May 1;290(18):11601-10
pubmed: 25771539
J Med Chem. 2019 Apr 11;62(7):3773-3779
pubmed: 30883119
Genes Dev. 2015 Nov 15;29(22):2343-8
pubmed: 26543161
Mech Ageing Dev. 2015 Mar;146-148:42-52
pubmed: 25843235
Commun Biol. 2018 Nov 2;1:183
pubmed: 30417120
J Biol Chem. 2014 Jun 6;289(23):16046-56
pubmed: 24753253
Org Biomol Chem. 2015 Apr 14;13(14):4149-54
pubmed: 25712161
Nature. 2010 Aug 26;466(7310):1125-8
pubmed: 20668449