Peripherally Crowded Cationic Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
22
01
2021
accepted:
22
02
2021
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
20
3
2021
Statut:
epublish
Résumé
Photodynamic therapy is a treatment modality of cancer based on the production of cytotoxic species upon the light activation of photosensitizers. Zinc phthalocyanine photosensitizers bearing four or eight bulky 2,6-di(pyridin-3-yl)phenoxy substituents were synthesized, and pyridyl moieties were methylated. The quaternized derivatives did not aggregate at all in water and retained their good photophysical properties. High photodynamic activity of these phthalocyanines was demonstrated on HeLa, MCF-7, and EA.hy926 cells with a very low EC
Identifiants
pubmed: 33738078
doi: 10.1021/acsmedchemlett.1c00045
pmc: PMC7958147
doi:
Types de publication
Journal Article
Langues
eng
Pagination
502-507Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
J Photochem Photobiol B. 2019 Feb;191:128-134
pubmed: 30616037
Chem Rev. 2015 Feb 25;115(4):1990-2042
pubmed: 25602130
Photochem Photobiol. 2020 May;96(3):506-516
pubmed: 31820824
Chem Rec. 2008;8(2):75-97
pubmed: 18366105
Angew Chem Int Ed Engl. 2020 Oct 12;59(42):18786-18794
pubmed: 32652750
J Mater Chem B. 2020 Jan 14;8(2):282-289
pubmed: 31803886
Chem Commun (Camb). 2015 Mar 18;51(22):4704-7
pubmed: 25692672
J Med Chem. 2017 Jul 27;60(14):6060-6076
pubmed: 28558213
Cancers (Basel). 2017 Feb 18;9(2):
pubmed: 28218708
J Med Chem. 2014 May 22;57(10):4088-97
pubmed: 24793456
Chem Soc Rev. 2018 Oct 1;47(19):7369-7400
pubmed: 30152500
Chem Soc Rev. 2020 Feb 21;49(4):1041-1056
pubmed: 31845688
Chem Commun (Camb). 2015 Nov 4;51(85):15550-3
pubmed: 26352730
Dalton Trans. 2016 Aug 16;45(33):13021-4
pubmed: 27396392
J Med Chem. 2020 Jul 23;63(14):7616-7632
pubmed: 32618190
J Med Chem. 2016 Oct 27;59(20):9443-9456
pubmed: 27682881
Apoptosis. 2019 Feb;24(1-2):184-197
pubmed: 30498998
ACS Nano. 2013 Aug 27;7(8):6988-96
pubmed: 23829542
Adv Mater. 2019 Sep;31(39):e1902582
pubmed: 31392780
Chem Commun (Camb). 2013 Dec 11;49(95):11149-51
pubmed: 24040651