Autologous Matrix-Induced Chondrogenesis for Treatment of Focal Cartilage Defects in the Knee: A Follow-up Study.
AMIC
cartilage
chondral
knee
repair
Journal
Orthopaedic journal of sports medicine
ISSN: 2325-9671
Titre abrégé: Orthop J Sports Med
Pays: United States
ID NLM: 101620522
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
09
07
2020
accepted:
17
08
2020
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
20
3
2021
Statut:
epublish
Résumé
Autologous matrix-induced chondrogenesis (AMIC) is a well-established treatment for full-thickness cartilage defects. To evaluate the long-term clinical outcomes of AMIC for the treatment of chondral lesions of the knee. Case series; Level of evidence, 4. A multisite prospective registry recorded demographic data and outcomes for patients who underwent repair of chondral defects. In total, 131 patients were included in the study. Lysholm, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) score for pain were used for outcome analysis. Across all patients, the mean ± SD age of patients was 36.6 ± 11.7 years. The mean body weight was 80.0 ± 16.8 kg, mean height was 176.3 ± 7.9 cm, and mean defect size was 3.3 ± 1.8 cm The median follow-up time for the patients in this cohort was 4.56 ± 2.92 years. Significant improvement ( AMIC is an effective method of treating chondral defects of the knee and leads to reliably favorable results up to 7 years postoperatively.
Sections du résumé
BACKGROUND
BACKGROUND
Autologous matrix-induced chondrogenesis (AMIC) is a well-established treatment for full-thickness cartilage defects.
PURPOSE
OBJECTIVE
To evaluate the long-term clinical outcomes of AMIC for the treatment of chondral lesions of the knee.
STUDY DESIGN
METHODS
Case series; Level of evidence, 4.
METHODS
METHODS
A multisite prospective registry recorded demographic data and outcomes for patients who underwent repair of chondral defects. In total, 131 patients were included in the study. Lysholm, Knee injury and Osteoarthritis Outcome Score (KOOS), and visual analog scale (VAS) score for pain were used for outcome analysis. Across all patients, the mean ± SD age of patients was 36.6 ± 11.7 years. The mean body weight was 80.0 ± 16.8 kg, mean height was 176.3 ± 7.9 cm, and mean defect size was 3.3 ± 1.8 cm
RESULTS
RESULTS
The median follow-up time for the patients in this cohort was 4.56 ± 2.92 years. Significant improvement (
CONCLUSION
CONCLUSIONS
AMIC is an effective method of treating chondral defects of the knee and leads to reliably favorable results up to 7 years postoperatively.
Identifiants
pubmed: 33738308
doi: 10.1177/2325967120981872
pii: 10.1177_2325967120981872
pmc: PMC7934047
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2325967120981872Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
The authors declared that they have no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.
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