Differentiation of Hodgkin lymphoma cells by reactive oxygen species and regulation by heme oxygenase-1 through HIF-1α.
Cell Differentiation
/ drug effects
Cell Hypoxia
Cell Line, Tumor
Cobalt
/ pharmacology
Gene Expression Regulation, Neoplastic
/ drug effects
Heme Oxygenase-1
/ genetics
Hodgkin Disease
/ genetics
Humans
Hydrogen Peroxide
/ pharmacology
Hypoxia-Inducible Factor 1, alpha Subunit
/ genetics
Protoporphyrins
/ pharmacology
Reactive Oxygen Species
/ metabolism
Hodgkin lymphoma
differentiation
heme oxygenase-1
hypoxia inducible factor 1
oxygen species
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
07
03
2021
received:
09
11
2020
accepted:
15
03
2021
pubmed:
20
3
2021
medline:
11
6
2021
entrez:
19
3
2021
Statut:
ppublish
Résumé
We previously indicated that Hodgkin lymphoma (HL) cells contain a small side population (SP) that differentiate into a large major population (MP) with giant Hodgkin and Reed-Sternberg (H and RS)-like cells. However, its molecular mechanisms are not fully understood. In this study, we found that intracellular reactive oxygen species (ROS) are low in the SP compared to the MP. Hydrogen peroxide induces large H- and RS-like cells in HL cell lines, but induces cell death in unrelated lymphoid cell lines. Microarray analyses revealed the enrichment of upregulated genes under hypoxic conditions in the SP compared to the MP, and we verified that the SP cells are hypoxic. Hypoxia inducible factor (HIF)-1α was preferentially expressed in the SP. CoCl
Identifiants
pubmed: 33738869
doi: 10.1111/cas.14890
pmc: PMC8177765
doi:
Substances chimiques
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Protoporphyrins
0
Reactive Oxygen Species
0
zinc protoporphyrin
15442-64-5
Cobalt
3G0H8C9362
Hydrogen Peroxide
BBX060AN9V
HMOX1 protein, human
EC 1.14.14.18
Heme Oxygenase-1
EC 1.14.14.18
cobaltous chloride
EVS87XF13W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2542-2555Subventions
Organisme : Japan Agency for Medical Research and Development
ID : 19fk0108039h0003
Organisme : Japan Agency for Medical Research and Development
ID : 20fk0108126h0001
Organisme : Japan Society for the Promotion of Science
ID : 17K08728
Organisme : Japan Society for the Promotion of Science
ID : 19K07442
Organisme : Japan Society for the Promotion of Science
ID : 19K16580
Organisme : Japan Society for the Promotion of Science
ID : 20K07379
Informations de copyright
© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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