Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.


Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
05 2021
Historique:
revised: 05 02 2021
received: 28 12 2020
pubmed: 20 3 2021
medline: 22 5 2021
entrez: 19 3 2021
Statut: ppublish

Résumé

Near-infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision medicine. However, most of these agents face the challenges of unstable optical properties, material-associated toxicity, and nonbiodegradability, all of which limit their biomedical application. Several croconaine-based organic agents able to overcome some of these limitations have been recently reported, but these suffer from complicated multistep synthesis protocols. Herein, the use of CR760, a croconaine dye with excellent optical properties, is reported for nanoparticle formulation and subsequent optoacoustic imaging and photothermal therapy. Importantly, CR760 can be conveniently prepared in a single step from commercially available materials. Furthermore, CR760 can be covalently attached, via a polyethylene glycol linker, to the α

Identifiants

pubmed: 33738974
doi: 10.1002/adhm.202002115
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2002115

Informations de copyright

© 2021 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

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Auteurs

Nian Liu (N)

Chair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Patrick O'Connor (P)

Institute of Medicinal Chemistry, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Institute of Structural Biology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Vipul Gujrati (V)

Chair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Dimitris Gorpas (D)

Chair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Sarah Glasl (S)

Institute of Biological and Medical Imaging, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Andreas Blutke (A)

Research Unit Analytical Pathology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Axel Walch (A)

Research Unit Analytical Pathology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

Karin Kleigrewe (K)

Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, Freising, 85354, Germany.

Michael Sattler (M)

Institute of Structural Biology, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Bavarian NMR Center and Center for Integrated Protein Science Munich, Technical University of Munich, Garching, 85747, Germany.

Oliver Plettenburg (O)

Institute of Medicinal Chemistry, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.
Center for Biomolecular Research, Institute of Organic Chemistry, Leibniz Universität Hannover, Hannover, 30167, Germany.

Vasilis Ntziachristos (V)

Chair of Biological Imaging, Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, 81675, Germany.
Institute of Biological and Medical Imaging, Helmholtz Zentrum München (GmbH), Neuherberg, 85764, Germany.

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