Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation.
degradation
silk fibroin
soft tissue regeneration
therapeutic ultrasound
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
22
02
2021
received:
09
01
2021
pubmed:
20
3
2021
medline:
9
6
2021
entrez:
19
3
2021
Statut:
ppublish
Résumé
A patient's capacity for tissue regeneration varies based on age, nutritional status, disease state, lifestyle, and gender. Because regeneration cannot be predicted prior to biomaterial implantation, there is a need for responsive biomaterials with adaptive, personalized degradation profiles to improve regenerative outcomes. This study reports a new approach to use therapeutic ultrasound as a means of altering the degradation profile of silk fibroin biomaterials noninvasively postimplantation. By evaluating changes in weight, porosity, surface morphology, compressive modulus, and chemical structure, it is concluded that therapeutic ultrasound can trigger enhanced degradation of silk fibroin scaffolds noninvasively. By removing microbubbles on the scaffold surface, it is found that acoustic cavitation is the mechanism responsible for changing the degradation profile. This method is proved to be safe for human cells with no negative effects on cell viability or metabolism. Sonication through human skin also effectively triggers scaffold degradation, increasing the clinical relevance of these results. These findings suggest that silk is an ultrasound-responsive biomaterial, where the degradation profile can be adjusted noninvasively to improve regenerative outcomes.
Identifiants
pubmed: 33738976
doi: 10.1002/adhm.202100048
doi:
Substances chimiques
Biocompatible Materials
0
Silk
0
Fibroins
9007-76-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100048Subventions
Organisme : NIH HHS
ID : MH114233
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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