Long-term treated HIV infection is associated with platelet mitochondrial dysfunction.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
18 03 2021
Historique:
received: 09 11 2020
accepted: 01 03 2021
entrez: 19 3 2021
pubmed: 20 3 2021
medline: 28 10 2021
Statut: epublish

Résumé

HIV infection and antiretroviral therapy have been linked to mitochondrial dysfunction. The role of platelet mitochondrial dysfunction in thrombosis, immunoregulation and age-related diseases is increasingly appreciated. Here, we studied platelet mitochondrial DNA content (mtDNA

Identifiants

pubmed: 33739024
doi: 10.1038/s41598-021-85775-5
pii: 10.1038/s41598-021-85775-5
pmc: PMC7973809
doi:

Substances chimiques

Anti-HIV Agents 0
DNA, Mitochondrial 0
Zidovudine 4B9XT59T7S

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6246

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Auteurs

Wouter A van der Heijden (WA)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands. Wouter.vanderHeijden@radboudumc.nl.

Lisa van de Wijer (L)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.

Martin Jaeger (M)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.

Karin Grintjes (K)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.

Mihai G Netea (MG)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Department for Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.

Rolf T Urbanus (RT)

Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Reinout van Crevel (R)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.

Lambertus P van den Heuvel (LP)

Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Translational Metabolic Laboratory, Department Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

Maaike Brink (M)

Translational Metabolic Laboratory, Department Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

Richard J Rodenburg (RJ)

Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

Philip G de Groot (PG)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Synapse Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.

Andre J van der Ven (AJ)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.

Quirijn de Mast (Q)

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.

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Classifications MeSH