Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

CFR COVID-19 Case fatality risk Coronavirus Mortality SARS-CoV-2 Variant of concern

Journal

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452

Informations de publication

Date de publication:
03 2021
Historique:
entrez: 19 3 2021
pubmed: 20 3 2021
medline: 25 3 2021
Statut: ppublish

Résumé

The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.

Identifiants

pubmed: 33739254
doi: 10.2807/1560-7917.ES.2021.26.11.2100256
pmc: PMC7976383
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V015737/1
Pays : United Kingdom

Références

Science. 2021 Mar 3;:
pubmed: 33658326
BMJ. 2021 Jan 26;372:n230
pubmed: 33500262
Nature. 2021 Mar 15;:
pubmed: 33723411
BMC Public Health. 2021 Mar 11;21(1):484
pubmed: 33706738
BMJ. 2021 Mar 9;372:n579
pubmed: 33687922

Auteurs

Daniel J Grint (DJ)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Kevin Wing (K)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Elizabeth Williamson (E)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Helen I McDonald (HI)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Krishnan Bhaskaran (K)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

David Evans (D)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Stephen Jw Evans (SJ)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Alex J Walker (AJ)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

George Hickman (G)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Emily Nightingale (E)

Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Anna Schultze (A)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Christopher T Rentsch (CT)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Chris Bates (C)

The Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.

Jonathan Cockburn (J)

The Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.

Helen J Curtis (HJ)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Caroline E Morton (CE)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Sebastian Bacon (S)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Simon Davy (S)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Angel Ys Wong (AY)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Amir Mehrkar (A)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Laurie Tomlinson (L)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Ian J Douglas (IJ)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Rohini Mathur (R)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Paula Blomquist (P)

COVID-19 Outbreak Surveillance Team, Public Health England, London, United Kingdom.

Brian MacKenna (B)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Peter Ingelsby (P)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Richard Croker (R)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

John Parry (J)

The Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.

Frank Hester (F)

The Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.

Sam Harper (S)

The Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom.

Nicholas J DeVito (NJ)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Will Hulme (W)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

John Tazare (J)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Ben Goldacre (B)

The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
These authors contributed equally.

Liam Smeeth (L)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
These authors contributed equally.

Rosalind M Eggo (RM)

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
These authors contributed equally.

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Classifications MeSH