[Models of glomerular filtration barrier : New developments].
Modélisation de la barrière de filtration glomérulaire - Nouvelles avancées.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
11
11
2021
Statut:
ppublish
Résumé
In this article, we present the latest innovations to generate in vitro models of the glomerular filtration barrier. There is currently a growing interest for such model systems that allow to reduce the use of animal models. Methodologies to improve their physiological relevance have taken advantage of the development of induced pluripotent stem cells and of bioengineering, particularly tissue engineering. Here, we first introduce the methods to overcome the limitations of the currently used glomerular cells based on the use of stem cells. The different approaches to obtain podocytes, the most important cells in the glomerulus, are presented. Finally, we emphasize the importance of the glomerular microenvironment in maintaining the glomerular cell phenotype, which can be achieved by co-culturing different glomerular cells, integration of biomaterials mimicking the extracellular matrix and introduction of flows with microfluidics. Modélisation de la barrière de filtration glomérulaire - Nouvelles avancées. Nous présentons, dans cette revue, les dernières avancées concernant la modélisation in vitro de la barrière de filtration glomérulaire. Ces systèmes, permettant de réduire l’utilisation des modèles animaux, connaissent un intérêt croissant et bénéficient du développement de nos connaissances des cellules souches et de la bioingénierie. Nous discuterons les limites des modèles cellulaires glomérulaires actuels et nous introduirons les méthodes permettant d’obtenir des cellules glomérulaires à partir des cellules souches. Enfin, nous discuterons de l’importance du microenvironnement dans le maintien du phénotype, quels que soient les systèmes utilisés tels que la co-culture, les biomatériaux ou la microfluidique.
Autres résumés
Type: Publisher
(fre)
Modélisation de la barrière de filtration glomérulaire - Nouvelles avancées.
Identifiants
pubmed: 33739271
doi: 10.1051/medsci/2021010
pii: msc200265
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
242-248Informations de copyright
© 2021 médecine/sciences – Inserm.
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