Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers.
HIV
inflammation
metabolic
migrants
obesity
overweight
social
sub-Saharan Africa
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
16 11 2021
16 11 2021
Historique:
received:
09
12
2020
accepted:
18
03
2021
pubmed:
20
3
2021
medline:
26
2
2022
entrez:
19
3
2021
Statut:
ppublish
Résumé
We investigated the association between socioclinical, inflammatory, and metabolic markers and weight gain in people with human immunodeficiency virus (HIV) on combination antiretroviral therapy (cART). Individuals from the COPANA cohort of normal weight (body mass index [BMI], 18.5-24.9 [ calculated as weight in kilograms divided by height in meters squared) at cART initiation who achieved virological suppression (viral load, <50 copies/mL) and maintained it through 36 months of treatment were selected. Clinical, immunovirological, and socioeconomic data and inflammation (high-sensitivity C-reactive protein, CXCL10, CXCL8, interleukin 6, soluble tumor necrosis factor receptors 1 and 2, soluble CD14, and soluble CD16) and serum metabolic (glucose, insulin, lipid profile, adiponectin, and leptin) markers were assessed. Factors associated with becoming overweight (BMI, 25-29.9) or obese (BMI, ≥30) at 36 months were assessed using multivariate logistic regression models. After 36 months of cART, 32 of 158 people with HIV (20%) became overweight or obese (21% female; 65% born in France and 23% born in sub-Saharan Africa; median BMI at cART initiation, 22 [interquartile range, 21-23]). After adjustment, higher BMI, originating from sub-Saharan Africa, living in a couple, and higher soluble tumor necrosis factor receptor 2 and lower adiponectin concentrations at cART initiation were associated with becoming overweight or obese. Weight gain on cART is multifactorial. Special attention should be given to migrants from sub-Saharan Africa. Monocyte activation and adipocyte dysfunction at cART initiation affect weight regulation.
Sections du résumé
BACKGROUND
We investigated the association between socioclinical, inflammatory, and metabolic markers and weight gain in people with human immunodeficiency virus (HIV) on combination antiretroviral therapy (cART).
METHODS
Individuals from the COPANA cohort of normal weight (body mass index [BMI], 18.5-24.9 [ calculated as weight in kilograms divided by height in meters squared) at cART initiation who achieved virological suppression (viral load, <50 copies/mL) and maintained it through 36 months of treatment were selected. Clinical, immunovirological, and socioeconomic data and inflammation (high-sensitivity C-reactive protein, CXCL10, CXCL8, interleukin 6, soluble tumor necrosis factor receptors 1 and 2, soluble CD14, and soluble CD16) and serum metabolic (glucose, insulin, lipid profile, adiponectin, and leptin) markers were assessed. Factors associated with becoming overweight (BMI, 25-29.9) or obese (BMI, ≥30) at 36 months were assessed using multivariate logistic regression models.
RESULTS
After 36 months of cART, 32 of 158 people with HIV (20%) became overweight or obese (21% female; 65% born in France and 23% born in sub-Saharan Africa; median BMI at cART initiation, 22 [interquartile range, 21-23]). After adjustment, higher BMI, originating from sub-Saharan Africa, living in a couple, and higher soluble tumor necrosis factor receptor 2 and lower adiponectin concentrations at cART initiation were associated with becoming overweight or obese.
CONCLUSION
Weight gain on cART is multifactorial. Special attention should be given to migrants from sub-Saharan Africa. Monocyte activation and adipocyte dysfunction at cART initiation affect weight regulation.
Identifiants
pubmed: 33740044
pii: 6178947
doi: 10.1093/infdis/jiab151
doi:
Substances chimiques
Adiponectin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1570-1580Investigateurs
O B
(O)
F B
(F)
Robert Carlier
(R)
Rosemary Dray-Spira
(R)
M G
(M)
C G
(C)
L P
(L)
Lucie Marchand
(L)
L M
(L)
Ventzislava Petrov-Sanchez
(V)
L P
(L)
Christine Rouzioux
(C)
Rémonie Seng
(R)
Rodolphe Thiebaut
(R)
Jean-Paul Viard
(JP)
S A
(S)
F B
(F)
Abdellatif Essabbani
(A)
Tatiana Feitoza
(T)
C G
(C)
Alain-Serge Keita
(AS)
Rémonie Seng
(R)
J P T
(JP)
Laurent Tran
(L)
Soraya Fellahi
(S)
Jean-Philippe Bastard
(JP)
A Simon
(A)
D Beniken
(D)
P M Girard
(PM)
Z Ouazene
(Z)
B Lefebvre
(B)
J Lamarque
(J)
A Ameur
(A)
G Pialoux
(G)
J Chas
(J)
L Slama
(L)
F Z Makhoukhi
(FZ)
P Passe-Courtin
(P)
L Gérard
(L)
J M Molina
(JM)
C Lascoux-Combe
(C)
J Delgado
(J)
S Parlier
(S)
J F Bergmann
(JF)
V Delcey
(V)
P Sellier
(P)
A Rami
(A)
M Parrinello
(M)
O B
(O)
L Traore
(L)
A Benmammar
(A)
M Kassim
(M)
Y Yazdanpanah
(Y)
S Matheron
(S)
S Lariven
(S)
V Joly
(V)
C Rioux
(C)
F Louni
(F)
J Zelie
(J)
B Fantin
(B)
A Villemant
(A)
C Bazin
(C)
L Weiss
(L)
J Pavie
(J)
M Manea
(M)
G H Tarnier-Cochin
(GH)
D S
(D)
M P Pietri
(MP)
J P Viard
(JP)
A Maignan
(A)
M J Dulucq
(MJ)
F Boué
(F)
S A
(S)
I Kansau
(I)
D V
(D)
S Poirier
(S)
C G
(C)
O Lambotte
(O)
K Bourdic
(K)
J D Lelièvre
(JD)
C Chesnel
(C)
C Duvivier
(C)
O Lortholary
(O)
F Touam
(F)
D Rey
(D)
P Fischer
(P)
M L Batard And
(ML)
M Mohseni Zadeh
(M)
A Richard
(A)
G Blaison
(G)
M Martinot
(M)
A Pachard
(A)
D Neau
(D)
S Le Puil
(S)
P Morlat
(P)
S Caldato
(S)
L Bernard
(L)
M C Hallouin-Bernard
(MC)
O Bourgault
(O)
C Chirouze
(C)
M C Thiebaut-Drobacheff
(MC)
A Proust
(A)
Q Gardiennet
(Q)
J Reynes
(J)
C Crisol
(C)
C Tramoni
(C)
T May
(T)
M P Bouillon
(MP)
M Delestan
(M)
M André
(M)
A Meybeck
(A)
M C Marien
(MC)
J Moreau
(J)
M J Carmantrand
(MJ)
L Meddeb
(L)
I Poizot-Martin
(I)
M Guignard
(M)
C Blanco Bétancourt
(C)
A Ivanova
(A)
F Raffi
(F)
L Larmetand
(L)
H Hue
(H)
P Perré
(P)
A Pegeot
(A)
L Cotte
(L)
C Chidiac
(C)
S Ogoudjobi
(S)
D Makhloufi
(D)
S Gibert
(S)
A Cabié
(A)
S Abel
(S)
P Hochedez
(P)
F Ronin
(F)
A S Batalla
(AS)
C Cerland
(C)
S Pierre-François
(S)
B Roze
(B)
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.