RNA-based therapies: A cog in the wheel of lung cancer defense.
Animals
Antagomirs
Biomarkers, Tumor
Cancer Vaccines
Clinical Studies as Topic
Combined Modality Therapy
/ methods
Drug Evaluation, Preclinical
Genetic Therapy
/ methods
Humans
Lung Neoplasms
/ genetics
MicroRNAs
/ genetics
RNA
/ genetics
RNA Interference
RNA, Antisense
RNA, Messenger
/ genetics
Treatment Outcome
Antisense oligonucleotides
Lung cancer
RNA interference
anti-miRs
mRNA-vaccine
Journal
Molecular cancer
ISSN: 1476-4598
Titre abrégé: Mol Cancer
Pays: England
ID NLM: 101147698
Informations de publication
Date de publication:
19 03 2021
19 03 2021
Historique:
received:
29
12
2020
accepted:
23
02
2021
entrez:
20
3
2021
pubmed:
21
3
2021
medline:
1
12
2021
Statut:
epublish
Résumé
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading cause of death worldwide. Despite recent advances in therapies, the overall 5-year survival rate of LC remains less than 20%. The efficacy of current therapeutic approaches is compromised by inherent or acquired drug-resistance and severe off-target effects. Therefore, the identification and development of innovative and effective therapeutic approaches are critically desired for LC. The development of RNA-mediated gene inhibition technologies was a turning point in the field of RNA biology. The critical regulatory role of different RNAs in multiple cancer pathways makes them a rich source of targets and innovative tools for developing anticancer therapies. The identification of antisense sequences, short interfering RNAs (siRNAs), microRNAs (miRNAs or miRs), anti-miRs, and mRNA-based platforms holds great promise in preclinical and early clinical evaluation against LC. In the last decade, RNA-based therapies have substantially expanded and tested in clinical trials for multiple malignancies, including LC. This article describes the current understanding of various aspects of RNA-based therapeutics, including modern platforms, modifications, and combinations with chemo-/immunotherapies that have translational potential for LC therapies.
Identifiants
pubmed: 33740988
doi: 10.1186/s12943-021-01338-2
pii: 10.1186/s12943-021-01338-2
pmc: PMC7977189
doi:
Substances chimiques
Antagomirs
0
Biomarkers, Tumor
0
Cancer Vaccines
0
MicroRNAs
0
RNA, Antisense
0
RNA, Messenger
0
RNA
63231-63-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
54Subventions
Organisme : NCI NIH HHS
ID : R01 CA247471
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA195586
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA217798
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218545
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA241752
Pays : United States
Références
Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23068-23074
pubmed: 31672910
Chem Rev. 2020 Jul 21;:
pubmed: 32692162
Mol Ther Nucleic Acids. 2017 Mar 17;6:259-268
pubmed: 28325292
N Engl J Med. 2018 Sep 13;379(11):e18
pubmed: 30207917
Sci Transl Med. 2015 Nov 18;7(314):314ra185
pubmed: 26582900
Cell Death Dis. 2014 May 15;5:e1227
pubmed: 24832599
Mol Cancer. 2020 Nov 12;19(1):159
pubmed: 33176804
Cancer Cell. 2018 Jul 9;34(1):85-102.e9
pubmed: 29990503
Immunity. 2005 Aug;23(2):165-75
pubmed: 16111635
Oncol Lett. 2020 Oct;20(4):7
pubmed: 32774481
Nature. 2020 Sep;585(7823):107-112
pubmed: 32728218
J Virol. 2019 Sep 30;93(20):
pubmed: 31341054
Semin Cancer Biol. 2020 Jul 30;:
pubmed: 32738290
Cell. 2019 Mar 7;176(6):1248-1264
pubmed: 30849371
Mol Cancer. 2018 Jan 31;17(1):20
pubmed: 29386018
Clin Cancer Res. 2004 Jun 15;10(12 Pt 2):4266s-4269s
pubmed: 15217972
J Chin Med Assoc. 2020 Jan;83(1):8-14
pubmed: 31770191
Cell. 2012 Aug 31;150(5):895-908
pubmed: 22939619
Cancers (Basel). 2020 May 24;12(5):
pubmed: 32456277
Front Oncol. 2020 Oct 28;10:585292
pubmed: 33194732
Mol Ther. 2008 Nov;16(11):1833-40
pubmed: 18797453
J Thorac Oncol. 2018 Apr;13(4):521-532
pubmed: 29269008
J Immunother Cancer. 2018 Nov 16;6(1):119
pubmed: 30446007
Nucleic Acids Res. 2020 May 7;48(8):4521-4537
pubmed: 32170319
Cancer Sci. 2020 Mar;111(3):951-961
pubmed: 31925985
Mol Cancer. 2017 Jan 30;16(1):8
pubmed: 28137272
Cancer Res. 2014 Sep 15;74(18):5152-64
pubmed: 25136066
Int J Nanomedicine. 2019 May 15;14:3557-3569
pubmed: 31190812
Cancer Discov. 2018 Jul;8(7):822-835
pubmed: 29773717
Hepatology. 2017 Jul;66(1):57-68
pubmed: 28295463
N Engl J Med. 2020 Oct 15;383(16):1544-1555
pubmed: 32722908
Bioconjug Chem. 2012 Feb 15;23(2):147-57
pubmed: 21992697
Drug Deliv. 2020 Dec;27(1):1397-1411
pubmed: 33096948
Adv Pharm Bull. 2017 Sep;7(3):339-348
pubmed: 29071215
Nat Biotechnol. 2017 Mar;35(3):238-248
pubmed: 28244990
Cancers (Basel). 2020 Nov 20;12(11):
pubmed: 33233600
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Mar;13(2):e1677
pubmed: 33174364
Semin Cancer Biol. 2020 Nov 18;:
pubmed: 33220460
Essays Biochem. 2018 Oct 26;62(4):583-593
pubmed: 30072489
Mol Carcinog. 2019 Jul;58(7):1303-1313
pubmed: 31026380
Genes (Basel). 2020 Nov 20;11(11):
pubmed: 33233552
Cancer Cell. 2015 Jun 8;27(6):852-63
pubmed: 26004684
Mol Cancer. 2020 Feb 27;19(1):40
pubmed: 32106857
Nature. 2020 Dec 18;:
pubmed: 33340017
Science. 2016 Jun 17;352(6292):1408-12
pubmed: 27313037
Invest New Drugs. 2005 Jun;23(3):263-9
pubmed: 15868384
Cancer Gene Ther. 2019 Feb;26(1-2):32-40
pubmed: 29970897
N Engl J Med. 2006 Dec 14;355(24):2542-50
pubmed: 17167137
Cancers (Basel). 2020 Oct 11;12(10):
pubmed: 33050637
Adv Neurobiol. 2018;20:31-61
pubmed: 29916015
Mol Cancer. 2020 May 30;19(1):98
pubmed: 32473645
Signal Transduct Target Ther. 2020 Oct 30;5(1):251
pubmed: 33127890
ACS Appl Mater Interfaces. 2020 Oct 14;12(41):45830-45837
pubmed: 32936615
Cell. 2012 Aug 31;150(5):883-94
pubmed: 22939618
Nature. 2020 Oct;586(7830):567-571
pubmed: 32756549
Nat Commun. 2019 Sep 12;10(1):4148
pubmed: 31515477
J Clin Med. 2020 Jun 26;9(6):
pubmed: 32604776
Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C649-C663
pubmed: 31693399
Transl Lung Cancer Res. 2020 Oct;9(5):2233-2244
pubmed: 33209646
Free Radic Biol Med. 2016 Jul;96:67-77
pubmed: 27101738
Nature. 1970 Aug 8;227(5258):561-3
pubmed: 4913914
DNA Repair (Amst). 2019 Dec;84:102672
pubmed: 31371183
Cancer Gene Ther. 2020 Dec 9;:
pubmed: 33299140
Int J Mol Sci. 2017 Sep 21;18(10):
pubmed: 28934120
Thorac Cancer. 2017 Jan;8(1):51-53
pubmed: 27801981
Sci Transl Med. 2017 Mar 29;9(383):
pubmed: 28356508
J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):578-593
pubmed: 31849191
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Cell. 2015 Jun 4;161(6):1388-99
pubmed: 26046440
BMC Cancer. 2018 Sep 15;18(1):893
pubmed: 30219045
Cancer Res. 2020 Nov 25;:
pubmed: 33239430
Nat Rev Drug Discov. 2017 Mar;16(3):203-222
pubmed: 28209991
Genome Res. 2015 Oct;25(10):1456-65
pubmed: 26430155
MMWR Morb Mortal Wkly Rep. 2020 Dec 18;69(50):1922-1924
pubmed: 33332292
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1881-9
pubmed: 26976605
Nucleic Acids Res. 2016 Jan 29;44(2):852-62
pubmed: 26578598
Nat Rev Drug Discov. 2018 Oct;17(10):751-767
pubmed: 30190565
Lung Cancer Manag. 2020 Nov 23;10(1):LMT43
pubmed: 33318755
J Thorac Oncol. 2018 Jun;13(6):831-839
pubmed: 29578107
Mol Ther Oncolytics. 2020 Oct 10;19:208-217
pubmed: 33251333
Int J Clin Exp Pathol. 2019 Sep 01;12(9):3344-3356
pubmed: 31934177
Science. 2004 Mar 5;303(5663):1526-9
pubmed: 14976262
Biochem Biophys Res Commun. 2019 Jan 22;508(4):1067-1073
pubmed: 30553455
Clin Cancer Res. 2017 Dec 1;23(23):7312-7323
pubmed: 28912139
Nucleic Acids Res. 2017 Sep 19;45(16):9528-9546
pubmed: 28934489
Eur J Pharmacol. 2015 Dec 15;769:127-33
pubmed: 26548623
Mol Ther. 2018 Jun 6;26(6):1482-1493
pubmed: 29735366
Eur Rev Med Pharmacol Sci. 2018 Aug;22(15):4879-4887
pubmed: 30070323
Mol Ther Nucleic Acids. 2020 Aug 25;22:222-235
pubmed: 33230429
Nucleic Acid Ther. 2019 Apr;29(2):61-66
pubmed: 30562145
Nature. 2019 Nov;575(7782):299-309
pubmed: 31723286
Mol Cell. 2016 Oct 20;64(2):320-333
pubmed: 27720646
Nature. 2005 Dec 1;438(7068):685-9
pubmed: 16258535
J Cell Biol. 2012 Oct 29;199(3):407-12
pubmed: 23109665
Mol Oncol. 2020 Dec 19;:
pubmed: 33340250
Lung Cancer. 2015 Nov;90(2):267-73
pubmed: 26415992
Nature. 2001 May 24;411(6836):494-8
pubmed: 11373684
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
RNA. 2016 Feb;22(2):169-74
pubmed: 26787305
Cell. 2013 Oct 24;155(3):552-66
pubmed: 24243015
Biochemistry (Mosc). 2018 May;83(5):483-497
pubmed: 29738683
Trends Cancer. 2017 Oct;3(10):686-697
pubmed: 28958387
Acta Biomater. 2019 Nov;99:307-319
pubmed: 31513911
Sci Signal. 2019 Nov 26;12(609):
pubmed: 31772123
Mol Ther Nucleic Acids. 2020 Sep 16;22:471-483
pubmed: 33230450
Oncogene. 2015 Sep 10;34(37):4834-44
pubmed: 25486429
Mol Cancer. 2011 May 16;10:55
pubmed: 21575235
Diabetes. 2020 May;69(5):804-812
pubmed: 32312896
J Biol Chem. 2004 Mar 26;279(13):12542-50
pubmed: 14729660
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):941-6
pubmed: 22215596
Cell. 2017 Jun 29;170(1):5
pubmed: 28666123
Expert Opin Ther Pat. 2021 Mar;31(3):223-238
pubmed: 33315482
Annu Rev Cell Dev Biol. 2015;31:31-54
pubmed: 26443190
Nat Rev Cancer. 2019 Sep;19(9):495-509
pubmed: 31406302
Eur J Cancer. 2019 Feb;108:33-40
pubmed: 30616146
Int J Mol Sci. 2019 Aug 13;20(16):
pubmed: 31412612
J Biochem. 2017 Jan;161(1):27-35
pubmed: 28053143
Mol Cancer. 2020 Mar 2;19(1):47
pubmed: 32122355
Cell Death Dis. 2020 Dec 11;11(12):1048
pubmed: 33311449
Curr Treat Options Oncol. 2019 Feb 18;20(3):21
pubmed: 30778772
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3553-61
pubmed: 25114235
Ann Oncol. 2002 Apr;13(4):539-45
pubmed: 12056703
J Cancer Res Clin Oncol. 2020 Dec;146(12):3333-3339
pubmed: 32632581
Science. 2005 Sep 2;309(5740):1577-81
pubmed: 16141076
Drug Dev Ind Pharm. 2020 Nov;46(11):1862-1872
pubmed: 32924641
Ann N Y Acad Sci. 2008 Nov;1143:45-60
pubmed: 19076344
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Dev Biol. 2016 Aug 15;416(2):338-46
pubmed: 27341756
Mol Cell. 2020 Mar 5;77(5):1032-1043.e4
pubmed: 31924447
Int J Mol Sci. 2020 Dec 03;21(23):
pubmed: 33287230
ACS Nano. 2020 Dec 8;:
pubmed: 33290659
Nat Rev Drug Discov. 2014 Oct;13(10):759-80
pubmed: 25233993
Macromol Biosci. 2016 Oct;16(10):1442-1449
pubmed: 27273465
Semin Cancer Biol. 2020 Oct;65:28-37
pubmed: 31866479
J Mol Biol. 2020 Dec 4;432(24):166712
pubmed: 33197462
Lancet. 2011 Nov 12;378(9804):1741-55
pubmed: 21565397
Mol Cancer. 2020 Apr 17;19(1):78
pubmed: 32303268
Front Endocrinol (Lausanne). 2020 Oct 06;11:563816
pubmed: 33123088
J Biol Chem. 2004 Apr 23;279(17):17181-9
pubmed: 14960586
Crit Rev Oncol Hematol. 2021 Jan;157:103194
pubmed: 33316418
N Engl J Med. 2020 Jun 11;382(24):2289-2301
pubmed: 32521132
Mol Cancer. 2020 Feb 26;19(1):38
pubmed: 32101138
Cancer Res. 1994 Jan 1;54(1):6-8
pubmed: 8261463
Nucleic Acids Res. 2020 Jul 27;48(13):7027-7040
pubmed: 32542340
Clin Cancer Res. 2016 Apr 15;22(8):1897-906
pubmed: 27084743
Nature. 2015 Oct 22;526(7574):591-4
pubmed: 26458103
J Cancer. 2019 Jun 9;10(15):3560-3570
pubmed: 31293661
Int J Mol Sci. 2020 Dec 06;21(23):
pubmed: 33291316
Nat Rev Cancer. 2019 May;19(5):289-297
pubmed: 30926931
NAR Cancer. 2020 Sep;2(3):zcaa025
pubmed: 33015625
Cancer Manag Res. 2020 Dec 08;12:12593-12602
pubmed: 33324104
Biomed Pharmacother. 2020 May;125:109997
pubmed: 32062550
Cancer. 2004 Jan 15;100(2):321-6
pubmed: 14716767
Med Sci Monit. 2019 Jul 21;25:5418-5425
pubmed: 31326971
Theranostics. 2019 Oct 22;9(26):8362-8376
pubmed: 31754402
Cancer Immunol Immunother. 2019 May;68(5):799-812
pubmed: 30770959
Protein Sci. 2021 Jan;30(1):218-233
pubmed: 33146890
Curr Opin Chem Biol. 2016 Feb;30:46-51
pubmed: 26625014
Br J Haematol. 2018 Nov;183(3):428-444
pubmed: 30125933
Mol Ther. 2013 Aug;21(8):1559-69
pubmed: 23774791
Nanomedicine. 2019 Aug;20:102007
pubmed: 31085346
Mol Ther. 2017 Sep 6;25(9):2075-2092
pubmed: 28663102
Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6086-93
pubmed: 15447994
Nat Rev Drug Discov. 2020 Dec;19(12):839-859
pubmed: 33077937
Cell. 2018 Mar 22;173(1):20-51
pubmed: 29570994
Cell. 2015 Nov 5;163(4):999-1010
pubmed: 26593424
Ann Transl Med. 2020 Oct;8(20):1297
pubmed: 33209877
Nucleic Acids Res. 2020 Mar 18;48(5):2531-2543
pubmed: 31965181
Biomaterials. 2014 Dec;35(38):10058-69
pubmed: 25277774
Viruses. 2020 Nov 02;12(11):
pubmed: 33147813
Mol Cancer. 2020 Dec 12;19(1):171
pubmed: 33308223
Nucleic Acids Res. 2019 Aug 22;47(14):7321-7332
pubmed: 31214713
J Thorac Oncol. 2020 Dec 14;:
pubmed: 33333327
Nat Commun. 2020 Jul 9;11(1):3501
pubmed: 32647108
J Invest Dermatol. 2019 May;139(5):1073-1081
pubmed: 30472058
Oncol Lett. 2018 Mar;15(3):2726-2734
pubmed: 29434997
J Clin Med. 2020 Nov 03;9(11):
pubmed: 33153004
J Viral Hepat. 2020 Jul;27(7):699-708
pubmed: 32096313
Ann Oncol. 2015 Feb;26(2):354-62
pubmed: 25467017
DNA Repair (Amst). 2019 Dec;84:102742
pubmed: 31708455
Sci Rep. 2020 Aug 4;10(1):13079
pubmed: 32753611
Epigenetics. 2017 Jun 3;12(6):416-432
pubmed: 28358281
Technol Cancer Res Treat. 2019 Jan-Dec;18:1533033819892263
pubmed: 31818225
Drug Dev Ind Pharm. 2017 Sep;43(9):1391-1401
pubmed: 28523942
Biochim Biophys Acta. 2011 May;1812(5):592-601
pubmed: 21315819
Biomed Pharmacother. 2020 Apr;124:109821
pubmed: 31962285
Mol Cancer Ther. 2018 Sep;17(9):1917-1926
pubmed: 29891486
Antimicrob Agents Chemother. 2015 Jan;59(1):599-608
pubmed: 25385103
Int J Mol Sci. 2020 May 02;21(9):
pubmed: 32370233
Lancet. 2017 Feb 18;389(10070):709-717
pubmed: 28087069
Oncologist. 2019 Dec;24(12):e1409-e1416
pubmed: 31420467
Lancet Oncol. 2013 Jan;14(1):3-5
pubmed: 23200176
Mol Cancer. 2020 Sep 24;19(1):145
pubmed: 32972405
Cell Mol Biol Lett. 2020 May 29;25:34
pubmed: 32514270
Lung Cancer. 2021 Jan;151:20-24
pubmed: 33279874
J Ocul Pharmacol Ther. 2013 Dec;29(10):855-64
pubmed: 24180627
Nat Rev Drug Discov. 2018 Apr;17(4):261-279
pubmed: 29326426
Genome Biol. 2012 Oct 31;13(10):175
pubmed: 23113984
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Annu Rev Med. 2019 Jan 27;70:307-321
pubmed: 30691367
Nat Cell Biol. 2017 Mar;19(3):238-251
pubmed: 28218907
Nat Biotechnol. 2016 Aug;34(8):875-80
pubmed: 27398791
Sci Transl Med. 2017 Jun 14;9(394):
pubmed: 28615361
Sci Transl Med. 2019 Jan 30;11(477):
pubmed: 30700577
Cancer Res. 2016 Jul 1;76(13):3666-70
pubmed: 27325641
N Engl J Med. 1987 Oct 8;317(15):929-35
pubmed: 3041218
Nat Rev Drug Discov. 2019 Jun;18(6):421-446
pubmed: 30846871
Nat Rev Drug Discov. 2020 Jul;19(7):441-442
pubmed: 32341501
Viruses. 2010 Jul;2(7):1382-93
pubmed: 21994685
Cell Res. 2014 Dec;24(12):1403-19
pubmed: 25412662
Stem Cell Rev Rep. 2020 Oct;16(5):828-852
pubmed: 32691369
Cell Metab. 2019 Feb 5;29(2):501
pubmed: 30726759
Lung Cancer. 2017 Apr;106:125-130
pubmed: 28285686
Nucleic Acids Res. 2017 Jul 27;45(13):7581-7592
pubmed: 28591791
Theranostics. 2019 Aug 12;9(20):5886-5898
pubmed: 31534526
J Neurochem. 2020 Apr;153(2):264-275
pubmed: 31811660
Methods Mol Biol. 2017;1517:3-22
pubmed: 27924471
J Clin Oncol. 2004 Mar 15;22(6):1110-7
pubmed: 15020613
Thorac Cancer. 2020 Mar;11(3):762-768
pubmed: 31994346
Biochim Biophys Acta. 2011 Dec;1813(12):2000-7
pubmed: 21878356
Nature. 2003 Sep 25;425(6956):415-9
pubmed: 14508493
Mayo Clin Proc. 2008 May;83(5):584-94
pubmed: 18452692
J Clin Oncol. 2008 Feb 20;26(6):870-6
pubmed: 18281659
Nat Biomed Eng. 2021 Feb;5(2):157-168
pubmed: 32929188
Nature. 2015 Aug 6;524(7563):47-53
pubmed: 26168399
Pharmacol Rev. 2020 Oct;72(4):862-898
pubmed: 32929000
Wiley Interdiscip Rev RNA. 2018 Jul;9(4):e1476
pubmed: 29693319
Nat Rev Clin Oncol. 2017 Sep;14(9):549-561
pubmed: 28534531
J Clin Invest. 2015 Jan;125(1):141-56
pubmed: 25415439
Nat Biotechnol. 2019 Aug;37(8):884-894
pubmed: 31375812
J Cell Mol Med. 2020 Mar;24(6):3549-3559
pubmed: 32052546
Annu Rev Pharmacol Toxicol. 2010;50:259-93
pubmed: 20055705
Nat Rev Genet. 2017 May;18(5):275-291
pubmed: 28216634
Curr Drug Metab. 2019;20(14):1114-1131
pubmed: 31902353
Cancer Cell Int. 2015 Nov 05;15:106
pubmed: 26549987
Thorac Cancer. 2021 Feb;12(3):372-381
pubmed: 33350095
Mol Cancer. 2019 Nov 4;18(1):153
pubmed: 31684958
Int J Pharm. 2016 May 30;505(1-2):24-34
pubmed: 27039150
J Thorac Oncol. 2014 Nov;9(11):1704-8
pubmed: 25436803
Nat Rev Drug Discov. 2020 Oct;19(10):673-694
pubmed: 32782413
N Engl J Med. 2008 May 8;358(19):2039-49
pubmed: 18463380
Nat Med. 2019 Nov;25(11):1783-1795
pubmed: 31700175
N Engl J Med. 2018 Jul 5;379(1):11-21
pubmed: 29972753
Nucleic Acid Ther. 2017 Oct;27(5):251-259
pubmed: 28796573
Cell. 2015 Jul 2;162(1):84-95
pubmed: 26140592
Wiley Interdiscip Rev RNA. 2020 Nov 23;:e1635
pubmed: 33230974
Mol Cancer. 2014 Apr 26;13:87
pubmed: 24767679
Nat Commun. 2020 Nov 27;11(1):6083
pubmed: 33247113
Annu Rev Biophys. 2013;42:217-39
pubmed: 23654304
Cell Rep. 2019 Nov 26;29(9):2890-2900.e5
pubmed: 31775053
Antiviral Res. 2020 Oct;182:104916
pubmed: 32798603
Oncol Lett. 2016 Nov;12(5):3836-3844
pubmed: 27895738
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9742-7
pubmed: 11481446
Nat Commun. 2016 Aug 09;7:12451
pubmed: 27501781
Mol Med Rep. 2021 Feb;23(2):1
pubmed: 33300085
Biochem Biophys Res Commun. 2021 Jan 1;534:254-260
pubmed: 33288197
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9522-9531
pubmed: 33015794
Nucleic Acids Res. 2019 Jul 26;47(13):6900-6916
pubmed: 31165876
Nat Cell Biol. 2014 Feb;16(2):191-8
pubmed: 24394384
Front Oncol. 2020 Oct 19;10:516850
pubmed: 33194579
Lung Cancer (Auckl). 2017 Dec 14;8:259-269
pubmed: 29276417
Mol Ther Nucleic Acids. 2017 Dec 15;9:263-273
pubmed: 29246305
Science. 2004 Sep 3;305(5689):1437-41
pubmed: 15284456
Bioorg Med Chem. 2020 Sep 15;28(18):115668
pubmed: 32828430
Nat Rev Drug Discov. 2009 Oct;8(10):806-23
pubmed: 19794444
Front Oncol. 2019 Sep 25;9:953
pubmed: 31612108
J Am Chem Soc. 2016 Jul 20;138(28):8694-7
pubmed: 27380263
Cancer Sci. 2020 Oct 28;:
pubmed: 33113263
Mol Cancer Ther. 2017 Aug;16(8):1511-1520
pubmed: 28468776
Nucleic Acids Res. 2016 Jun 20;44(11):5299-312
pubmed: 27131367
N Engl J Med. 2019 Feb 7;380(6):549-558
pubmed: 30726693
Pharm Res. 2017 Feb;34(2):310-320
pubmed: 27896589
N Engl J Med. 2013 May 2;368(18):1685-94
pubmed: 23534542
J Cell Mol Med. 2021 Feb;25(4):1911-1926
pubmed: 33350586
Pharm Res. 2016 Dec;33(12):2943-2953
pubmed: 27528390
Biochem Biophys Res Commun. 2013 Feb 15;431(3):623-9
pubmed: 23266614
Cell Metab. 2018 Apr 3;27(4):714-739
pubmed: 29617640
Cancer Cell. 2018 May 14;33(5):853-861.e4
pubmed: 29731394
Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):
pubmed: 29101115
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):185-192
pubmed: 30454892
Semin Cancer Biol. 2020 Apr;61:167-179
pubmed: 31562956
Curr Opin Plant Biol. 2018 Oct;45(Pt A):88-95
pubmed: 29883934
J Clin Oncol. 2006 Mar 20;24(9):1428-34
pubmed: 16549837
Cell. 2012 Apr 27;149(3):656-70
pubmed: 22541435
Eur J Cancer. 2015 Nov;51(16):2480-9
pubmed: 26254808
J Immunother Cancer. 2020 Jun;8(1):
pubmed: 32581048
Trends Genet. 2017 Mar;33(3):208-219
pubmed: 28174021
Methods Mol Biol. 2011;676:43-9
pubmed: 20931388
J Immunol. 2000 Oct 15;165(8):4710-7
pubmed: 11035115
Blood. 2003 Jul 15;102(2):571-6
pubmed: 12576330
Nucleic Acid Ther. 2017 Apr;27(2):70-77
pubmed: 28080221
Nat Biotechnol. 2017 Mar;35(3):230-237
pubmed: 28244996
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820977546
pubmed: 33302819
Thorac Cancer. 2020 Mar;11(3):549-560
pubmed: 31923353
Adv Exp Med Biol. 2017;983:129-146
pubmed: 28639196
Methods Mol Biol. 2017;1543:259-270
pubmed: 28349433
Mol Pharm. 2018 Oct 1;15(10):4722-4732
pubmed: 30138565
Nanomaterials (Basel). 2017 Apr 05;7(4):
pubmed: 28379201
Nature. 2014 Jan 2;505(7481):117-20
pubmed: 24284625
Drug Discov Today. 2020 Mar;25(3):552-560
pubmed: 31843577
Tanpakushitsu Kakusan Koso. 2009 Dec;54(16 Suppl):2086-91
pubmed: 21089622
BMC Cancer. 2017 Sep 27;17(1):661
pubmed: 28954633
J Thorac Oncol. 2012 Mar;7(3):579-86
pubmed: 22198426
Int J Mol Sci. 2020 Nov 20;21(22):
pubmed: 33233641
Cell Biol Int. 2020 Aug;44(8):1671-1680
pubmed: 32281700
Lung Cancer. 2017 Sep;111:65-68
pubmed: 28838401
Transl Lung Cancer Res. 2016 Jun;5(3):288-300
pubmed: 27413711
Cell. 2012 Jan 20;148(1-2):259-72
pubmed: 22225612
Drug Discov Today. 2015 Nov;20(11):1285-7
pubmed: 26365874
Sci Transl Med. 2014 Jun 11;6(240):240ps7
pubmed: 24920658
Crit Rev Oncol Hematol. 2017 Feb;110:1-12
pubmed: 28109399
Eur Rev Med Pharmacol Sci. 2019 Jun;23(12):5133-5138
pubmed: 31298366
J Immunother Cancer. 2019 Feb 8;7(1):38
pubmed: 30736848
Nat Struct Mol Biol. 2013 Jul;20(7):818-26
pubmed: 23748378