The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model.
Animals
Benzopyrans
Biomechanical Phenomena
Bone and Bones
/ metabolism
Collagen
/ metabolism
Disease Models, Animal
Injections, Intralesional
Ozone
/ administration & dosage
Platelet-Rich Plasma
Rabbits
Rotator Cuff
/ metabolism
Rotator Cuff Injuries
/ physiopathology
Tendons
/ metabolism
Treatment Outcome
Wound Healing
Ozone therapy
Platelet-rich plasma
Rotator cuff
Tendon-to-bone healing
Journal
Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112
Informations de publication
Date de publication:
19 Mar 2021
19 Mar 2021
Historique:
received:
12
11
2020
accepted:
22
02
2021
entrez:
20
3
2021
pubmed:
21
3
2021
medline:
18
9
2021
Statut:
epublish
Résumé
The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups. The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O
METHODS
METHODS
Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O
RESULTS
RESULTS
When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups.
CONCLUSIONS
CONCLUSIONS
The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.
Identifiants
pubmed: 33740995
doi: 10.1186/s13018-021-02320-w
pii: 10.1186/s13018-021-02320-w
pmc: PMC7976715
doi:
Substances chimiques
Benzopyrans
0
timefurone
0415629F6C
Ozone
66H7ZZK23N
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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