Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan.
HCP-style brain imaging
Harmonization protocol
Multi-site study
Neurological disorders
Psychiatric disorders
Traveling subjects
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
04
2020
revised:
31
01
2021
accepted:
12
02
2021
pubmed:
21
3
2021
medline:
31
7
2021
entrez:
20
3
2021
Statut:
ppublish
Résumé
Psychiatric and neurological disorders are afflictions of the brain that can affect individuals throughout their lifespan. Many brain magnetic resonance imaging (MRI) studies have been conducted; however, imaging-based biomarkers are not yet well established for diagnostic and therapeutic use. This article describes an outline of the planned study, the Brain/MINDS Beyond human brain MRI project (BMB-HBM, FY2018 ~ FY2023), which aims to establish clinically-relevant imaging biomarkers with multi-site harmonization by collecting data from healthy traveling subjects (TS) at 13 research sites. Collection of data in psychiatric and neurological disorders across the lifespan is also scheduled at 13 sites, whereas designing measurement procedures, developing and analyzing neuroimaging protocols, and databasing are done at three research sites. A high-quality scanning protocol, Harmonization Protocol (HARP), was established for five high-quality 3 T scanners to obtain multimodal brain images including T1 and T2-weighted, resting-state and task functional and diffusion-weighted MRI. Data are preprocessed and analyzed using approaches developed by the Human Connectome Project. Preliminary results in 30 TS demonstrated cortical thickness, myelin, functional connectivity measures are comparable across 5 scanners, suggesting sensitivity to subject-specific connectome. A total of 75 TS and more than two thousand patients with various psychiatric and neurological disorders are scheduled to participate in the project, allowing a mixed model statistical harmonization. The HARP protocols are publicly available online, and all the imaging, demographic and clinical information, harmonizing database will also be made available by 2024. To the best of our knowledge, this is the first project to implement a prospective, multi-level harmonization protocol with multi-site TS data. It explores intractable brain disorders across the lifespan and may help to identify the disease-specific pathophysiology and imaging biomarkers for clinical practice.
Identifiants
pubmed: 33741307
pii: S2213-1582(21)00044-9
doi: 10.1016/j.nicl.2021.102600
pmc: PMC8209465
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102600Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Brain. 2015 Jul;138(Pt 7):2059-73
pubmed: 25935725
NPJ Schizophr. 2016 Dec 13;2:1
pubmed: 28560246
Neuroimage. 2013 Dec;83:991-1001
pubmed: 23899722
Mol Psychiatry. 2016 Oct;21(10):1460-6
pubmed: 26782053
Prog Neurobiol. 2011 Dec;95(4):629-35
pubmed: 21930184
Nature. 2016 Aug 11;536(7615):171-178
pubmed: 27437579
Nat Neurosci. 2016 Aug 26;19(9):1175-87
pubmed: 27571196
Neuroimage. 2020 May 1;211:116604
pubmed: 32062083
Neuroimage. 2019 Jan 15;185:335-348
pubmed: 30332613
J Alzheimers Dis. 2017;60(1):295-304
pubmed: 28800325
Dev Sci. 2014 Sep;17(5):797-807
pubmed: 24636228
Neuroimage. 2018 Dec;183:972-984
pubmed: 30261308
J Neurosci. 2016 Jun 22;36(25):6758-70
pubmed: 27335406
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6356-E6365
pubmed: 29925602
Neuroimage. 2018 Feb 15;167:104-120
pubmed: 29155184
Nat Neurosci. 2015 Nov;18(11):1565-7
pubmed: 26414616
Mol Psychiatry. 2018 Apr;23(4):932-942
pubmed: 28461699
Dev Cogn Neurosci. 2018 Aug;32:43-54
pubmed: 29567376
Mol Psychiatry. 2020 Sep;25(9):2130-2143
pubmed: 30171211
Nat Neurosci. 2016 Nov;19(11):1523-1536
pubmed: 27643430
Int J Epidemiol. 2019 Oct 1;48(5):1414-1414g
pubmed: 30879075
Psychiatry Clin Neurosci. 2019 May;73(5):231-242
pubmed: 30588712
Neuroimage. 2018 Nov 1;181:692-717
pubmed: 29753843
Mol Psychiatry. 2017 Jun;22(6):900-909
pubmed: 27137745
Magn Reson Med. 2010 May;63(5):1144-53
pubmed: 20432285
Front Aging Neurosci. 2019 Sep 26;11:259
pubmed: 31616285
J Psychiatr Brain Sci. 2020;5:
pubmed: 32258424
Mol Psychiatry. 2016 Apr;21(4):547-53
pubmed: 26033243
Neuroimage. 2017 Nov 1;161:149-170
pubmed: 28826946
Neuroimage. 2016 Jan 15;125:479-497
pubmed: 26477650
J Neurosci. 2011 Aug 10;31(32):11597-616
pubmed: 21832190
Neuroimage. 2013 Oct 15;80:202-19
pubmed: 23707591
PLoS Biol. 2019 Apr 18;17(4):e3000042
pubmed: 30998673
PLoS Biol. 2020 Dec 7;18(12):e3000966
pubmed: 33284797
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
Nihon Rinsho. 2017 Jan;75(1):151-155
pubmed: 30566310
Alzheimers Dement. 2015 Jun;11(6):e1-120
pubmed: 26073027
Neuroimage. 2017 May 15;152:450-466
pubmed: 28284799
Sci Data. 2020 May 27;7(1):157
pubmed: 32461581
Neuroimage. 2003 Oct;20(2):870-88
pubmed: 14568458
Neuroimage. 2018 May 1;171:277-295
pubmed: 29277648
Schizophr Res. 2013 Jan;143(1):116-24
pubmed: 23219075
PLoS Med. 2008 Jul 1;5(7):e141
pubmed: 18597549
Lancet. 2012 Dec 15;380(9859):2197-223
pubmed: 23245608
Magn Reson Med. 2012 May;67(5):1210-24
pubmed: 21858868
Alzheimers Dement. 2018 Aug;14(8):1077-1087
pubmed: 29753531
Neuroimaging Clin N Am. 2005 Nov;15(4):869-77, xi-xii
pubmed: 16443497
Magn Reson Med. 2003 Nov;50(5):1077-88
pubmed: 14587019
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Neuroimage. 2018 Dec;183:456-468
pubmed: 30142446
Neuron. 2019 Feb 6;101(3):385-389
pubmed: 30731063
Cereb Cortex. 2020 Jul 30;30(9):5014-5027
pubmed: 32377664
Mol Psychiatry. 2016 Jun;21(6):806-12
pubmed: 26122586
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Curr Opin Neurobiol. 2020 Dec;65:120-128
pubmed: 33242721
Neuroimage. 2018 Nov 15;182:488-499
pubmed: 29448073
Neuroimage. 2012 Jul 16;61(4):1000-16
pubmed: 22484410
Neuroimage. 2020 May 1;211:116619
pubmed: 32044437
Neuroimage. 2020 Nov 1;221:117128
pubmed: 32673745
Neuroimage. 2018 Feb 15;167:453-465
pubmed: 29100940
Nat Commun. 2016 Apr 14;7:11254
pubmed: 27075704
Prog Neurobiol. 2009 Oct;89(2):220-30
pubmed: 19665515
Neuroimage. 2012 Oct 1;62(4):2222-31
pubmed: 22366334
Neuroimage. 2019 Jul 15;195:373-383
pubmed: 30935908
Front Neurosci. 2020 May 06;14:396
pubmed: 32435181
Biol Psychiatry. 2018 Sep 15;84(6):452-459
pubmed: 29779670
Neuroimage. 2016 Nov 1;141:191-205
pubmed: 27402600
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Neuroimage. 2016 Jul 1;134:396-409
pubmed: 27071694
Nature. 2018 Oct;562(7726):210-216
pubmed: 30305740
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
Front Aging Neurosci. 2016 Dec 08;8:298
pubmed: 28008314
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573