Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
03 2021
Historique:
received: 10 08 2020
accepted: 05 02 2021
entrez: 20 3 2021
pubmed: 21 3 2021
medline: 19 4 2022
Statut: epublish

Résumé

Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we introduce a novel translational approach to lower expression of the tau gene

Identifiants

pubmed: 33741591
pii: 7/12/eabe1611
doi: 10.1126/sciadv.abe1611
pmc: PMC7978433
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Transcription Factors 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059789
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG000222
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000046
Pays : United States

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Susanne Wegmann (S)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA. bzeitler@sangamo.com susanne.wegmann@dzne.de bhyman@mgh.harvard.edu.
German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.

Sarah L DeVos (SL)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Bryan Zeitler (B)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA. bzeitler@sangamo.com susanne.wegmann@dzne.de bhyman@mgh.harvard.edu.

Kimberly Marlen (K)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Rachel E Bennett (RE)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Marta Perez-Rando (M)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Danny MacKenzie (D)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Qi Yu (Q)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Caitlin Commins (C)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Riley N Bannon (RN)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Bianca T Corjuc (BT)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Alison Chase (A)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Lisa Diez (L)

German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.

Hoang-Oanh B Nguyen (HB)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Sarah Hinkley (S)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Lei Zhang (L)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Alicia Goodwin (A)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Annemarie Ledeboer (A)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Stephen Lam (S)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Irina Ankoudinova (I)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Hung Tran (H)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Nicholas Scarlott (N)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Rainier Amora (R)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Richard Surosky (R)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Jeffrey C Miller (JC)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Ashley B Robbins (AB)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.

Edward J Rebar (EJ)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Fyodor D Urnov (FD)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Michael C Holmes (MC)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Amy M Pooler (AM)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Brigit Riley (B)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

H Steve Zhang (HS)

Sangamo Therapeutics Inc., Richmond, CA 94804, USA.

Bradley T Hyman (BT)

Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA. bzeitler@sangamo.com susanne.wegmann@dzne.de bhyman@mgh.harvard.edu.

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