Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells.
Algorithms
Cluster Analysis
Connective Tissue
/ diagnostic imaging
Humans
Image Processing, Computer-Assisted
Immunity, Innate
Interferon Regulatory Factors
/ metabolism
Interleukin-7 Receptor alpha Subunit
/ metabolism
Lymphocytes
/ immunology
Machine Learning
Palatine Tonsil
/ diagnostic imaging
Phenotype
Spatial Analysis
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 03 2021
19 03 2021
Historique:
received:
05
05
2020
accepted:
23
02
2021
entrez:
20
3
2021
pubmed:
21
3
2021
medline:
7
4
2021
Statut:
epublish
Résumé
Innate lymphoid cells (ILCs) emerge in the last few years as important regulators of immune responses and biological processes. Although ILCs are mainly known as tissue-resident cells, their precise localization and interactions with the microenvironment are still unclear. Here we combine a multiplexed immunofluorescence technique and a customized computational, open-source analysis pipeline to unambiguously identify CD127
Identifiants
pubmed: 33741932
doi: 10.1038/s41467-021-21994-8
pii: 10.1038/s41467-021-21994-8
pmc: PMC7979823
doi:
Substances chimiques
Interferon Regulatory Factors
0
Interleukin-7 Receptor alpha Subunit
0
interferon regulatory factor-4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1737Références
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