Alpha-lipoic acid supplementation increases the efficacy of exercise- and diet-induced obesity treatment and induces immunometabolic changes in female mice and women.
Aged
Animals
Body Composition
CD4-Positive T-Lymphocytes
Diet, High-Fat
/ adverse effects
Dietary Supplements
Energy Metabolism
/ immunology
Exercise
Female
Glucose Tolerance Test
Humans
Lipid Peroxidation
Mice, Inbred C57BL
Middle Aged
Obesity
/ therapy
Palmitates
/ metabolism
Physical Conditioning, Animal
Random Allocation
Thioctic Acid
/ administration & dosage
T lymphocyte
antioxidant
diet
exercise
immunometabolism
inflammation
regulatory T cells
translational study
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
11
12
2020
received:
29
07
2020
accepted:
14
12
2020
entrez:
20
3
2021
pubmed:
21
3
2021
medline:
22
7
2021
Statut:
ppublish
Résumé
The decrease in the regulatory T cells (Tregs) population is highly involved in adipose tissue inflammation and insulin resistance in obesity. Tregs depend on fatty acids via β-oxidation for immunosuppressive function adapting their antioxidant systems to allow survival to oxidative stress. In this study, we have hypothesized that a dietary supplementation with alpha-lipoic acid (ALA), a powerful antioxidant, would improve immunometabolism when added to the classical strategy of obesity treatment. First, we showed by in vitro experiments that ALA favors the polarization of mice CD4 + T cells toward Tregs. Next, we have carried out a translational study where female obese mice and women were supplemented with ALA or vehicle/placebo (mice: 2.5 g
Identifiants
pubmed: 33742689
doi: 10.1096/fj.202001817RR
doi:
Substances chimiques
Palmitates
0
Thioctic Acid
73Y7P0K73Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21312Informations de copyright
© 2021 Federation of American Societies for Experimental Biology.
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