Pregnancy in Inflammatory Bowel Disease: Experience of a Chilean cohort.
Embarazo en enfermedad inflamatoria intestinal: experiencia en una cohorte chilena.
Colitis ulcerosa
Consejo preconcepcional
Crohńs disease
Embarazo
Enfermedad de Crohn
Enfermedad inflamatoria intestinal
Inflammatory bowel disease
Preconception counselling
Pregnancy
Ulcerative colitis
Journal
Gastroenterologia y hepatologia
ISSN: 0210-5705
Titre abrégé: Gastroenterol Hepatol
Pays: Spain
ID NLM: 8406671
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
19
06
2020
revised:
12
08
2020
accepted:
25
08
2020
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
5
11
2021
Statut:
ppublish
Résumé
In inflammatory bowel disease (IBD) a high percentage of women are diagnosed during their reproductive age. IBD in remission is the ideal scenario when planning a pregnancy. To describe the clinical characteristics of pregnancy/newborn and assess disease activity at the time of conception and throughout the pregnancy in patients with IBD treated at a tertiary centre in Chile. We retrospectively reviewed women diagnosed with IBD who were pregnant or delivered between 2017 and 2020. Demographic, clinical, obstetric and delivery data were obtained from the IBD registry, approved by the local IRB. Descriptive statistics and association tests were performed (χ2, p ≤ 0.05). Sixty women with IBD were included. At the beginning of pregnancy, 21 (35%) had active disease and 39 (65%) were in remission. Of those with active disease, 16 (66%) remained active and 6 had spontaneous abortions. In those who were in remission, 26 (69%) remained in this condition. Nine patients (15%) discontinued treatment, and 6 of these had inflammatory activity during pregnancy. Preconception counselling was performed in 23 of the 60 patients, being higher in the group that remained in remission during pregnancy (65% vs. 35%, p = 0.02). Patients who had a flare during pregnancy had more probability of preterm birth (<37 weeks) and newborn with lower weight compared with the group that always remained in remission (89% vs. 74%, p = 0.161) and (2.885 vs 3.370 g; p = 0.0014). Remission presents better outcomes in pregnancy and preconception counselling would allow a better IBD control during pregnancy.
Sections du résumé
BACKGROUND
BACKGROUND
In inflammatory bowel disease (IBD) a high percentage of women are diagnosed during their reproductive age. IBD in remission is the ideal scenario when planning a pregnancy.
AIMS
OBJECTIVE
To describe the clinical characteristics of pregnancy/newborn and assess disease activity at the time of conception and throughout the pregnancy in patients with IBD treated at a tertiary centre in Chile.
METHODS
METHODS
We retrospectively reviewed women diagnosed with IBD who were pregnant or delivered between 2017 and 2020. Demographic, clinical, obstetric and delivery data were obtained from the IBD registry, approved by the local IRB. Descriptive statistics and association tests were performed (χ2, p ≤ 0.05).
RESULTS
RESULTS
Sixty women with IBD were included. At the beginning of pregnancy, 21 (35%) had active disease and 39 (65%) were in remission. Of those with active disease, 16 (66%) remained active and 6 had spontaneous abortions. In those who were in remission, 26 (69%) remained in this condition. Nine patients (15%) discontinued treatment, and 6 of these had inflammatory activity during pregnancy. Preconception counselling was performed in 23 of the 60 patients, being higher in the group that remained in remission during pregnancy (65% vs. 35%, p = 0.02). Patients who had a flare during pregnancy had more probability of preterm birth (<37 weeks) and newborn with lower weight compared with the group that always remained in remission (89% vs. 74%, p = 0.161) and (2.885 vs 3.370 g; p = 0.0014).
CONCLUSION
CONCLUSIONS
Remission presents better outcomes in pregnancy and preconception counselling would allow a better IBD control during pregnancy.
Identifiants
pubmed: 33745519
pii: S0210-5705(20)30320-4
doi: 10.1016/j.gastrohep.2020.08.005
pii:
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
277-285Informations de copyright
Copyright © 2020 Elsevier España, S.L.U. All rights reserved.