Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference.

Disease Management Disease Susceptibility Humans Mastocytosis / complications Research Translational Research, Biomedical
American Initiative in Mast Cell Diseases (AIM) European Competence Network on Mastocytosis (ECNM) Systemic mastocytosis anaphylaxis hereditary alpha-tryptasemia mast cell activation syndrome siglec-8

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
06 2021
Historique:
received: 15 01 2021
revised: 28 02 2021
accepted: 05 03 2021
pubmed: 23 3 2021
medline: 5 10 2021
entrez: 22 3 2021
Statut: ppublish

Résumé

The American Initiative in Mast Cell Diseases (AIM) held its inaugural investigator conference at Stanford University School of Medicine in May 2019. The overarching goal of this meeting was to establish a Pan-American organization of physicians and scientists with multidisciplinary expertise in mast cell disease. To serve this unmet need, AIM envisions a network where basic, translational, and clinical researchers could establish collaborations with both academia and biopharma to support the development of new diagnostic methods, enhanced understanding of the biology of mast cells in human health and disease, and the testing of novel therapies. In these AIM proceedings, we highlight selected topics relevant to mast cell biology and provide updates regarding the recently described hereditary alpha-tryptasemia. In addition, we discuss the evaluation and treatment of mast cell activation (syndromes), allergy and anaphylaxis in mast cell disorders, and the clinical and biologic heterogeneity of the more indolent forms of mastocytosis. Because mast cell disorders are relatively rare, AIM hopes to achieve a coordination of scientific efforts not only in the Americas but also in Europe by collaborating with the well-established European Competence Network on Mastocytosis.

Identifiants

DOI: 10.1016/j.jaci.2021.03.008 PMID: 33745886 PMC: PMC9521380
pubmed: 33745886
pii: S0091-6749(21)00376-6
doi: 10.1016/j.jaci.2021.03.008
pmc: PMC9521380
mid: NIHMS1697387
pii:
doi:

Types de publication

Congress Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2043-2052

Subventions

Organisme : NCATS NIH HHS
ID : R13 TR002722
Pays : United States

Informations de copyright

Copyright © 2021 American Academy of Allergy, Asthma & Immunology. All rights reserved.

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Auteurs

Jason Gotlib (J)

Division of Hematology, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, Calif. Electronic address: jason.gotlib@stanford.edu.

Tracy I George (TI)

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah.

Melody C Carter (MC)

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

K Frank Austen (KF)

Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, Mass.

Bruce Bochner (B)

Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Daniel F Dwyer (DF)

Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, Mass.

Jonathan J Lyons (JJ)

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Matthew J Hamilton (MJ)

Division of Gastroenterology, Hepatology and Endoscopy. Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

Joseph Butterfield (J)

Mayo Clinic, Division of Allergic Diseases, Rochester, Minn.

Patrizia Bonadonna (P)

Allergy Unit, Verona University Hospital, Verona, Italy.

Catherine Weiler (C)

Mayo Clinic, Division of Allergic Diseases, Rochester, Minn.

Stephen J Galli (SJ)

Department of Pathology, Stanford University School of Medicine, Stanford, Calif; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, Calif.

Lawrence B Schwartz (LB)

Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Virginia Commonwealth University, Richmond, Va.

Hanneke Oude Elberink (HO)

Internal Medicine, Section Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Anne Maitland (A)

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Theoharis Theoharides (T)

Department of Immunology, Tufts University School of Medicine, Boston, Mass.

Celalettin Ustun (C)

Division of Hematology, Oncology and Cellular Therapy, Department of Medicine, Rush University, Chicago, Ill.

Hans-Peter Horny (HP)

Institute of Pathology, Ludwig-Maximilian-University, Munich, Germany.

Alberto Orfao (A)

Servicio Central de Citometria, Centro de Investigacion del Cancer (IBMCC, CSIC/USAL), IBSAL, CIBERONC and Department of Medicine, University of Salamanca, Salamanca, Germany.

Michael Deininger (M)

Division of Hematology and Hematologic Malignancies, The University of Utah, and Huntsman Cancer Institute, Salt Lake City, Utah.

Deepti Radia (D)

Department of Clinical Haematology, Guys and St Thomas' NHS Hospitals, London, United Kingdom.

Mohamad Jawhar (M)

University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Hanneke Kluin-Nelemans (H)

Department of Haematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Dean D Metcalfe (DD)

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Michel Arock (M)

Laboratory of Haematology, Pitié-Salpêtrière Hospital, Paris, France.

Wolfgang R Sperr (WR)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.

Peter Valent (P)

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.

Mariana Castells (M)

Brigham and Women's Hospital, Division of Allergy and Clinical Immunology, Boston, Mass; Harvard Medical School, Boston, Mass.

Cem Akin (C)

Division of Allergy and Immunology, University of Michigan, Ann Arbor, Mich.

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