Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.
Animals
DNA-Binding Proteins
/ genetics
Drosophila
/ metabolism
Drosophila Proteins
/ genetics
Embryonic Development
/ genetics
Eye
/ embryology
Female
Gene Expression Regulation, Developmental
/ genetics
Hedgehog Proteins
/ genetics
Male
RNA-Binding Proteins
/ genetics
Sex Characteristics
Sex Determination Processes
/ genetics
Sex Differentiation
/ genetics
Sex Factors
Signal Transduction
/ genetics
Drosophila
Eye development
Eye disc
Organ growth
Sexual dimorphism
Signaling pathways
Journal
Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
04
10
2020
revised:
07
02
2021
accepted:
01
03
2021
pubmed:
23
3
2021
medline:
13
10
2021
entrez:
22
3
2021
Statut:
ppublish
Résumé
Understanding molecular mechanisms of sexually dimorphic organ growth is a fundamental problem of developmental biology. Recent quantitative studies showed that the Drosophila compound eye is a convenient model to study the determination of the final organ size. In Drosophila, females have larger eyes than males and this is evident even after correction for the larger body size. Moreover, female eyes include more ommatidia (photosensitive units) than male eyes and this difference is specified at the third larval instar in the eye primordia called eye imaginal discs. This may result in different visual capabilities between the two sexes and have behavioral consequences. Despite growing evidence on the genetic bases of eye size variation between different Drosophila species and strains, mechanisms responsible for within-species sexual dimorphism still remain elusive. Here, we discuss a presumptive crosstalk between the sex determination cascade and major signaling pathways during dimorphic eye development. Male- and female-specific isoforms of Doublesex (Dsx) protein are known to control sex-specific differentiation in the somatic tissues. However, no data on Dsx function during eye disc growth and patterning are currently available. Remarkably, Sex lethal (Sxl), the sex determination switch protein, was shown to directly affect Hedgehog (Hh) and Notch (N) signaling in the Drosophila wing disc. The similarity of signaling pathways involved in the wing and eye disc growth suggests that Sxl might be integrated into regulation of eye development. Dsx role in the eye disc requires further investigation. We discuss currently available data on sex-biased gene expression in the Drosophila eye and highlight perspectives for future studies.
Identifiants
pubmed: 33745943
pii: S0012-1606(21)00064-6
doi: 10.1016/j.ydbio.2021.03.005
pmc: PMC8172476
mid: NIHMS1689209
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
DSX protein, Drosophila
0
Drosophila Proteins
0
Hedgehog Proteins
0
RNA-Binding Proteins
0
Sxl protein, Drosophila
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-52Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM128193
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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