Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP.
dibenzoylhydrazine
ecdysone receptor
imidazole
ligand-binding domain
structural adaptation
water channel
Journal
Journal of pesticide science
ISSN: 1348-589X
Titre abrégé: J Pestic Sci
Pays: Japan
ID NLM: 101580833
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
ppublish
Résumé
The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as insecticidal dibenzoylhydrazines (DBHs). Here, we report the crystal structures of the ligand-binding domains of
Identifiants
pubmed: 33746550
doi: 10.1584/jpestics.D20-095
pmc: PMC7953031
doi:
Types de publication
Journal Article
Langues
eng
Pagination
88-100Informations de copyright
© Pesticide Science Society of Japan 2021. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Déclaration de conflit d'intérêts
Conflict of InterestThe authors declare that they have no conflict of interest.
Références
Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1954-64
pubmed: 25004972
Nature. 2003 Nov 6;426(6962):91-6
pubmed: 14595375
J Biol Chem. 2003 Oct 3;278(40):38821-8
pubmed: 12819202
J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):55-9
pubmed: 15225747
Bioorg Med Chem. 2009 Jun 15;17(12):4064-70
pubmed: 19168365
J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):127-37
pubmed: 15860255
Mol Syst Biol. 2016 Apr 22;12(4):864
pubmed: 27107013
EMBO Rep. 2007 Jun;8(6):563-8
pubmed: 17468738
Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9
pubmed: 2025413
Nat Rev Drug Discov. 2015 Feb;14(2):95-110
pubmed: 25614222
Pest Manag Sci. 2003 Jan;59(1):36-48
pubmed: 12558098
Nat Commun. 2014 Jun 19;5:4139
pubmed: 24942373
J Biol Chem. 2007 Nov 9;282(45):32924-34
pubmed: 17848566
Bioorg Med Chem Lett. 2003 Feb 10;13(3):475-8
pubmed: 12565954
Steroids. 1984 Mar;43(3):243-59
pubmed: 6523542
Cell. 1992 Oct 2;71(1):63-72
pubmed: 1327536
J Biol Chem. 2016 Dec 2;291(49):25281-25291
pubmed: 27694446
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
FEBS J. 2009 Nov;276(21):6128-57
pubmed: 19796154
Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21
pubmed: 9757107
Vitam Horm. 2005;73:131-73
pubmed: 16399410
Annu Rev Entomol. 2012;57:83-106
pubmed: 22017307
J Am Chem Soc. 2007 Mar 7;129(9):2577-87
pubmed: 17288418
Methods Enzymol. 1997;276:307-26
pubmed: 27754618
J Biol Chem. 2005 Jun 10;280(23):22258-69
pubmed: 15809296
Pest Manag Sci. 2003 Jan;59(1):49-57
pubmed: 12558099
Annu Rev Entomol. 1998;43:545-69
pubmed: 9444757
J Comput Aided Mol Des. 2003 Feb-Apr;17(2-4):135-53
pubmed: 13677482
Nature. 1993 Dec 2;366(6454):476-9
pubmed: 8247157
Bioorg Med Chem. 2019 Mar 15;27(6):1065-1075
pubmed: 30770256
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Insect Biochem Mol Biol. 2011 Dec;41(12):932-7
pubmed: 21958716
Mol Cell Biol. 2008 Mar;28(6):1915-23
pubmed: 18160712
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
J Med Chem. 2006 Aug 24;49(17):5199-205
pubmed: 16913708
Pest Manag Sci. 2001 Feb;57(2):115-9
pubmed: 11455641
Cell. 1991 Oct 4;67(1):59-77
pubmed: 1913820
J Mol Biol. 2013 Jul 10;425(13):2317-29
pubmed: 23499886
J Biol Chem. 2001 Mar 9;276(10):7465-74
pubmed: 11053444
Nature. 1993 Apr 1;362(6419):471-5
pubmed: 8385270
Annu Rev Entomol. 2013;58:251-71
pubmed: 23072463
Bioorg Med Chem Lett. 2003 Jun 2;13(11):1883-6
pubmed: 12749890
Protein Eng. 2002 Aug;15(8):697-705
pubmed: 12364585
EMBO J. 2007 Aug 22;26(16):3770-82
pubmed: 17673910
Protein Sci. 2000 Jun;9(6):1073-84
pubmed: 10892801
Acta Crystallogr D Biol Crystallogr. 1994 Mar 1;50(Pt 2):178-85
pubmed: 15299456
J Med Chem. 2008 Feb 28;51(4):1063-7
pubmed: 18232647