Revisiting nature: a review of iridoids as a potential antileishmanial class.
Antileishmanial
Iridoids
Leishmaniasis
Natural products
Neglected tropical diseases
Journal
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe
ISSN: 1568-7767
Titre abrégé: Phytochem Rev
Pays: Netherlands
ID NLM: 101198162
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
09
2020
accepted:
02
03
2021
pubmed:
23
3
2021
medline:
23
3
2021
entrez:
22
3
2021
Statut:
ppublish
Résumé
Leishmaniasis still stands as one of the most prevalent neglected tropical diseases in the least developed and emerging countries. The recommended therapeutic arsenal to treat leishmaniasis is characterized by several shortcomings, and resistance has already been reported. Hence, this dramatic background highlights the pressing need to develop novel, affordable, and safe antileishmanial drugs. Multiple classes of natural compounds have been reported to possess antileishmanial activity. Among these classes, iridoids stand out as a special type of monoterpenoids with diverse biological properties-including their antileishmanial potential. This review aims to discuss the available literature between 1991 and 2020 related to the antileishmanial activity of the iridoid class. Throughout the past decades, various investigations attributed antileishmanial action to assorted iridoid types, including inhibitory potential towards validated drug targets and immunomodulatory activity. The latter deserves special attention due to the ability of some iridoids to improve the host's immune response against parasites. It opens the possibility of iridoids become adjuncts in leishmaniasis treatments by improving the efficacy of currently employed drugs. Furthermore, the present study intends to provide a convenient visual representation of which iridoids and
Identifiants
pubmed: 33746658
doi: 10.1007/s11101-021-09750-8
pii: 9750
pmc: PMC7960493
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
101-126Informations de copyright
© The Author(s), under exclusive licence to Springer Nature B.V. 2021.
Déclaration de conflit d'intérêts
Conflicts of interestThe authors have no conflicts of interest to declare.
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