Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma.
Journal
Case reports in genetics
ISSN: 2090-6544
Titre abrégé: Case Rep Genet
Pays: United States
ID NLM: 101583302
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
02
2021
revised:
24
02
2021
accepted:
28
02
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
Intracranial undifferentiated pleomorphic sarcoma remains a rare pathology within the sarcoma literature that may arise primarily or secondary after radiation therapy. Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens, clinical prognosis remains exceedingly poor. Furthermore, there is a lack of genetic or molecular characterization to guide potential for targeted therapies. We present genomic analysis of a radiation-induced intracranial undifferentiated pleomorphic sarcoma in an 83-year-old woman with notable KIT and PDGFRA alterations. Further similar genomic studies of intracranial pleomorphic sarcoma are needed to develop better therapies for this rare but challenging disease entity.
Identifiants
pubmed: 33747576
doi: 10.1155/2021/5586072
pmc: PMC7960067
doi:
Types de publication
Case Reports
Langues
eng
Pagination
5586072Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2021 Christopher S. Hong et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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