BAFF receptor antibody for mantle cell lymphoma therapy.
Mantle Cell Lymphoma
adcc
baff
drug resistance
nk cells
therapy
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
05 03 2021
05 03 2021
Historique:
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Mantle cell lymphoma (MCL) is an aggressive form of B cell non-Hodgkin's lymphoma and remains incurable under current treatment modalities. One of the main reasons for treatment failure is the development of drug resistance. Accumulating evidence suggests that B cell activating factor (BAFF) and BAFF receptor (BAFF-R) play an important role in the proliferation and survival of malignant B cells. High serum BAFF levels are often correlated with poor drug response and relapse in MCL patients. Our study shows that BAFF-R is expressed on both MCL patient cells and cell lines. BAFF-R knockdown leads to MCL cell death showing the importance of BAFF-R signaling in MCL survival. Moderate knockdown of BAFF-R in MCL cells did not affect its viability, but sensitized them to cytarabine treatment
Identifiants
pubmed: 33747637
doi: 10.1080/2162402X.2021.1893501
pii: 1893501
pmc: PMC7939563
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
B-Cell Activating Factor
0
B-Cell Activation Factor Receptor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1893501Subventions
Organisme : NCI NIH HHS
ID : R21 CA201775
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007250
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002549
Pays : United States
Informations de copyright
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
J.W is an employee at Novartis pharma. R.P is a scientific advisory board member of Luminary Therapeutics
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