Feasibility of a Dielectric Elastomer Augmented Aorta.
artificial muscles
augmented aortas
cardiac assist devices
dielectric elastomer actuators
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
26
05
2020
revised:
09
10
2020
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric-elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. In vitro experiments using a pulsatile flow-loop, replicating human physiological flow and pressure conditions, show a reduction of 5.5% (47 mJ per cycle) of the heart energy with this device. Here, the controlled stiffness of the DEA graft, which is usually difficult to exploit for actuators, is perfectly matching the assistance principle. At the same time, the physiological aortic pressure is exploited to offer a prestretch to the DEA which otherwise would require an additional bulky pre-stretching system to reach high performances.
Identifiants
pubmed: 33747718
doi: 10.1002/advs.202001974
pii: ADVS2287
pmc: PMC7967089
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2001974Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Cardiovasc Drugs Ther. 1995 Feb;9(1):73-83
pubmed: 7786838
Bioengineered. 2017 Mar 4;8(2):154-170
pubmed: 27588460
Crit Care. 2016 Jun 25;20(1):153
pubmed: 27342573
ASAIO J. 2011 Jan-Feb;57(1):19-25
pubmed: 20980912
PLoS One. 2018 Mar 16;13(3):e0194384
pubmed: 29547668
Croat Med J. 2014 Dec;55(6):609-20
pubmed: 25559832
Circ Res. 2013 Aug 30;113(6):646-59
pubmed: 23989710
Xenotransplantation. 2008 Nov-Dec;15(6):384-9
pubmed: 19152666
Interact Cardiovasc Thorac Surg. 2018 Jun 1;26(6):1002-1008
pubmed: 29415164
J Vis Exp. 2016 Feb 01;(108):e53423
pubmed: 26863283
Ann Thorac Surg. 2005 Mar;79(3):872-80
pubmed: 15734398
J Appl Physiol (1985). 2009 Nov;107(5):1497-503
pubmed: 19729593
Eur J Cardiothorac Surg. 2015 May;47(5):e172-8; discussion e178-9
pubmed: 25719178
Physiol Rev. 1954 Oct;34(4):619-42
pubmed: 13215088
Eur J Vasc Endovasc Surg. 2018 Apr;55(4):560-566
pubmed: 29402669
ACS Appl Mater Interfaces. 2019 Sep 11;11(36):33323-33335
pubmed: 31464413
ACS Biomater Sci Eng. 2016 Sep 12;2(9):1546-1558
pubmed: 33440590
Vascul Pharmacol. 2014 Feb;60(2):52-6
pubmed: 24380840
J Mech Behav Biomed Mater. 2014 Dec;40:339-353
pubmed: 25265032
Interact Cardiovasc Thorac Surg. 2017 Feb 1;24(2):173-180
pubmed: 27680580
J Heart Valve Dis. 2008 Nov;17(6):606-13
pubmed: 19137790
J Thorac Cardiovasc Surg. 1999 Jan;117(1):164-71
pubmed: 9869771
Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1481-91
pubmed: 22227124
Hypertension. 2015 May;65(5):1015-9
pubmed: 25776078
Adv Sci (Weinh). 2021 Jan 25;8(6):2001974
pubmed: 33747718
Biomaterials. 1992;13(1):38-43
pubmed: 1543807
Heart Lung Circ. 2005 Sep;14(3):178-86
pubmed: 16352274
Am J Cardiol. 1971 Jan;27(1):3-11
pubmed: 5538711
Ann Thorac Surg. 1999 Nov;68(5):1668-75
pubmed: 10585040
Sci Robot. 2019 Dec 18;4(37):
pubmed: 33137720
Eur J Cardiothorac Surg. 2009 Sep;36(3):580-4
pubmed: 19464915
Curr Heart Fail Rep. 2010 Mar;7(1):27-34
pubmed: 20425494