Impact on the Gut Microbiota of Intensive and Prolonged Antimicrobial Therapy in Patients With Bone and Joint Infection.
antibiotics
antimicrobial therapy
bone and joint infection
dysbiosis
gut microbiota
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
07
2020
accepted:
25
01
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
There is a growing interest in the potentially deleterious impact of antibiotics on gut microbiota. Patients with bone and joint infection (BJI) require prolonged treatment that may impact significantly the gut microbiota. We collected samples from patients with BJI at baseline, end of antibiotics (EOT), and 2 weeks after antibiotic withdrawal (follow-up, FU) in a multicenter prospective cohort in France. Microbiota composition was determined by shotgun metagenomic sequencing. Fecal markers of gut permeability and inflammation as well as multi-drug-resistant bacteria (MDRB) and
Identifiants
pubmed: 33748154
doi: 10.3389/fmed.2021.586875
pmc: PMC7977441
doi:
Types de publication
Journal Article
Langues
eng
Pagination
586875Informations de copyright
Copyright © 2021 Levast, Benech, Gasc, Batailler, Senneville, Lustig, Pouderoux, Boutoille, Boucinha, Dauchy, Zeller, Maynard, Cazanave, Le Thi, Josse, Doré, Laurent and Ferry.
Déclaration de conflit d'intérêts
BL and CG are employed by the commercial company MaaT Pharma. LB was employed by the commercial company MaaT Pharma. NB declared a travel grant from Maat. JD is co-founder of MaaT Pharma. TF received advisory honorarium from MaaT Pharma and was the principal investigator of this study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from MaaT Pharma. The funder had the following involvement in the study: design, management and analysis.
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