Undenatured Type II Collagen Ameliorates Inflammatory Responses and Articular Cartilage Damage in the Rat Model of Osteoarthritis.
MIA
Nf-κB
UC-II
inflammation
osteoarthritis
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
12
2020
accepted:
20
01
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
Osteoarthritis (OA) is an age-related joint disease that includes gradual disruption of the articular cartilage and the resulting pain. The present study was designed to test the effects of undenatured type II collagen (UC-II®) on joint inflammation in the monoiodoacetate (MIA) OA model. We also investigated possible mechanisms underlying these effects. Female Wistar rats were divided into three groups: (i) Control; (ii) MIA-induced rats treated with vehicle; (iii) MIA-induced rats treated with UC-II (4 mg/kg BW). OA was induced in rats by intra-articular injection of MIA (1 mg) after seven days of UC-II treatment. UC-II reduced MIA-induced Kellgren-Lawrence scoring (53.3%,
Identifiants
pubmed: 33748207
doi: 10.3389/fvets.2021.617789
pmc: PMC7970046
doi:
Types de publication
Journal Article
Langues
eng
Pagination
617789Informations de copyright
Copyright © 2021 Orhan, Juturu, Sahin, Tuzcu, Ozercan, Durmus, Sahin and Sahin.
Déclaration de conflit d'intérêts
VJ an employee of Lonza Consumer Health (NJ, USA). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet. 2015 Jul 25;386(9991):376-87
pubmed: 25748615
Trends Biochem Sci. 2004 Feb;29(2):72-9
pubmed: 15102433
Clin Exp Med. 2011 Sep;11(3):137-45
pubmed: 21069419
Nat Rev Rheumatol. 2017 May;13(5):302-311
pubmed: 28381830
Arthritis Res Ther. 2013;15(6):R208
pubmed: 24314202
J Bone Joint Surg Am. 1971 Apr;53(3):523-37
pubmed: 5580011
J Exp Orthop. 2018 Jun 15;5(1):21
pubmed: 29904905
Biochim Biophys Acta. 2016 Apr;1862(4):576-591
pubmed: 26769361
Osteoarthritis Cartilage. 2006 Sep;14(9):839-48
pubmed: 16730463
Bioelectromagnetics. 2018 Feb;39(2):89-97
pubmed: 29251361
J Pain Res. 2017 Aug 21;10:1973-1989
pubmed: 28860852
Sci Rep. 2019 Apr 24;9(1):6366
pubmed: 31019213
Arthritis Rheum. 1997 Sep;40(9):1670-9
pubmed: 9324022
Biosci Biotechnol Biochem. 2020 Feb;84(2):402-410
pubmed: 31642732
J Am Coll Nutr. 2015;34(3):255-62
pubmed: 25751538
Ann Rheum Dis. 2010 Sep;69(9):1623-8
pubmed: 20525836
Vet Sci. 2019 Sep 04;6(3):
pubmed: 31487772
Osteoarthritis Cartilage. 2013 Jan;21(1):10-5
pubmed: 23041436
Endocr Metab Immune Disord Drug Targets. 2006 Dec;6(4):383-94
pubmed: 17214584
Neurobiol Pain. 2019 Sep 03;6:100036
pubmed: 31535058
Int J Clin Pharmacol Res. 2002;22(3-4):101-10
pubmed: 12837047
Int J Med Sci. 2009 Oct 09;6(6):312-21
pubmed: 19847319
Ann Rheum Dis. 1957 Dec;16(4):494-502
pubmed: 13498604
Pharmacol Biochem Behav. 2011 Mar;98(1):35-42
pubmed: 21147151
Gait Posture. 2018 Jun;63:73-79
pubmed: 29723651
BMC Complement Altern Med. 2018 Feb 20;18(1):69
pubmed: 29463254
Biol Res. 2015 Nov 17;48:64
pubmed: 26578310
Biomed Pharmacother. 2016 Oct;83:763-770
pubmed: 27484345
Clin Chim Acta. 2006 Mar;365(1-2):68-77
pubmed: 16257399
Osteoarthritis Cartilage. 2017 Dec;25(12):2080-2090
pubmed: 28888901
J Clin Invest. 1998 Apr 15;101(8):1596-603
pubmed: 9541489
Clin Sports Med. 2019 Jan;38(1):1-15
pubmed: 30466716
Inflamm Res. 2010 May;59(5):369-77
pubmed: 19862478
Arthritis Rheum. 2003 Mar;48(3):602-11
pubmed: 12632410
Ann Rheum Dis. 2006 Jan;65(1):40-4
pubmed: 16126801
World J Orthop. 2017 Jan 18;8(1):1-11
pubmed: 28144573
J Cell Physiol. 2017 Nov;232(11):2957-2963
pubmed: 28425564
Arthritis Rheum. 2012 Apr;64(4):1046-56
pubmed: 22076939
Pain. 2019 Feb;160(2):486-492
pubmed: 30371559
J Orthop Res. 2013 Jul;31(7):999-1006
pubmed: 23423905
Nat Rev Rheumatol. 2011 Jan;7(1):33-42
pubmed: 21119608
Nutr J. 2016 Jan 29;15:14
pubmed: 26822714
J Med Food. 2013 Nov;16(11):1039-45
pubmed: 24175655
Mod Rheumatol. 2009;19(6):581-9
pubmed: 19697097