Learning deficit in cognitively normal APOE ε4 carriers with LOW β-amyloid.
Alzheimer's disease
amyloid
apolipoprotein E
learning
memory
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
08
2020
revised:
12
10
2020
accepted:
13
10
2020
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ-) apolipoprotein E ( Aβ- CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) over 6 days. Aβ- ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non-carriers (d = 0.3). Rates of learning on the ORCA-LLT were significantly slower in Aβ- ε4 carriers compared to non-carriers (d = 1.2). In Aβ- CNs, ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA-LLT. Alzheimer's disease (AD)-related cognitive abnormalities can manifest before preclinical AD thresholds.
Identifiants
pubmed: 33748392
doi: 10.1002/dad2.12136
pii: DAD212136
pmc: PMC7962170
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12136Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
YY Lim, J Baker, A Mills, L Bruns Jr, C Fowler, J Fripp, SR Rainey‐Smith, D Ames, CL Masters, and P Maruff report no conflicts of interest related to the article.
Références
J Neurosci Methods. 2002 Mar 15;114(2):173-9
pubmed: 11856568
Alzheimers Dement. 2010 May;6(3):291-6
pubmed: 20451879
Alzheimers Dement. 2015 Jan;11(1):1-15.e1-4
pubmed: 25443857
Alzheimers Dement (Amst). 2020 Jul 09;12(1):e12055
pubmed: 32671181
Nat Rev Neurol. 2013 Feb;9(2):106-18
pubmed: 23296339
Neuropsychology. 2019 Oct;33(7):964-974
pubmed: 31368758
Neurology. 2014 May 20;82(20):1760-7
pubmed: 24748674
Ann Neurol. 2013 Dec;74(6):905-13
pubmed: 24448836
JAMA Neurol. 2018 Apr 1;75(4):488-494
pubmed: 29356823
Neuroimage. 2005 Apr 15;25(3):958-68
pubmed: 15808996
Neurology. 2020 Nov 3;95(18):e2577-e2585
pubmed: 32887774
J Prev Alzheimers Dis. 2017;4(2):87-92
pubmed: 28966919
Neurology. 2018 Apr 24;90(17):e1452-e1460
pubmed: 29572282
Neurology. 2017 Sep 5;89(10):1028-1034
pubmed: 28794245
Neuropsychology. 2015 Nov;29(6):940-8
pubmed: 26011114
Ann Neurol. 2011 Jan;69(1):181-92
pubmed: 21280088
Alzheimers Dement (Amst). 2016 Oct 18;6:108-121
pubmed: 28239636
Neuroimage. 2018 Dec;183:387-393
pubmed: 30130643
J Clin Exp Neuropsychol. 2020 Feb;42(1):55-65
pubmed: 31514573
JAMA. 2019 Jun 18;321(23):2316-2325
pubmed: 31211344
Int Psychogeriatr. 2009 Aug;21(4):672-87
pubmed: 19470201
Brain. 2014 Jan;137(Pt 1):221-31
pubmed: 24176981