Loss of antibodies to hepatitis E virus in organ transplant patients with hepatitis E.
antibodies
hepatitis E
positive-to-negative conversion
transplant
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN: 1386-6346
Titre abrégé: Hepatol Res
Pays: Netherlands
ID NLM: 9711801
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
10
02
2021
received:
10
09
2020
accepted:
14
03
2021
pubmed:
23
3
2021
medline:
23
3
2021
entrez:
22
3
2021
Statut:
ppublish
Résumé
Studies regarding changes in antibodies to hepatitis E virus (HEV) after HEV infection in organ transplant patients are limited. This study aimed to clarify HEV infection trends in organ transplant patients who contracted HEV using data from a previous Japanese nationwide survey. This study was undertaken from 2012 to 2019. Among 4518 liver, heart, and kidney transplant patients, anti-HEV immunoglobulin G (IgG) antibodies were positive in 164; data were collected from 106 of these patients, who consented to participate in the study. In total, 32 liver transplant patients, seven heart transplant patients, and 67 kidney transplant patients from 16 institutions in Japan were examined for IgG, IgM, and IgM antibodies to HEV and the presence of HEV RNA in the serum. The χ Anti-HEV IgG positive-to-negative conversion occurred in 25 (23.6%) of 106 organ transplant patients. Of eight patients with hepatitis E who tested positive for HEV RNA, one (14.0%) had anti-HEV IgG positive-to-negative conversion. Twenty-four (24.5%) of 98 patients negative for HEV RNA had anti-HEV IgG positive-to-negative conversion. This study revealed, for the first time, the changes in HEV antibodies in organ transplant patients. Loss of anti-HEV IgG could often occur unexpectedly in organ transplant patients with previous HEV infection.
Types de publication
Journal Article
Langues
eng
Pagination
538-547Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP19fk0210043
Informations de copyright
© 2021 The Japan Society of Hepatology.
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