Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow.
Amino Acid Sequence
Anti-HIV Agents
/ chemistry
Binding Sites
Capsid Proteins
/ antagonists & inhibitors
Cell Line, Tumor
HEK293 Cells
HIV-1
/ drug effects
Humans
Indoles
/ chemistry
Microbial Sensitivity Tests
Microsomes, Liver
/ metabolism
Molecular Docking Simulation
Protein Binding
Protein Stability
Stereoisomerism
Workflow
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
08 04 2021
08 04 2021
Historique:
pubmed:
23
3
2021
medline:
8
6
2021
entrez:
22
3
2021
Statut:
ppublish
Résumé
Poor metabolic stability of the human immunodeficiency virus type-1 (HIV-1) capsid (CA) inhibitor
Identifiants
pubmed: 33750123
doi: 10.1021/acs.jmedchem.0c01810
pmc: PMC8043142
mid: NIHMS1686511
doi:
Substances chimiques
Anti-HIV Agents
0
Capsid Proteins
0
Indoles
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3747-3766Subventions
Organisme : NIAID NIH HHS
ID : R01 AI150491
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089435
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI118415
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH079785
Pays : United States
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