Evaluating the effect of spaceflight on the host-pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium.
Journal
NPJ microgravity
ISSN: 2373-8065
Titre abrégé: NPJ Microgravity
Pays: United States
ID NLM: 101703605
Informations de publication
Date de publication:
09 Mar 2021
09 Mar 2021
Historique:
received:
27
08
2020
accepted:
03
02
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
23
3
2021
Statut:
epublish
Résumé
Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host-pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.
Identifiants
pubmed: 33750813
doi: 10.1038/s41526-021-00136-w
pii: 10.1038/s41526-021-00136-w
pmc: PMC7943786
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9Subventions
Organisme : NASA | Ames Research Center
ID : NNX09AH40G
Organisme : NASA | Ames Research Center
ID : NNX09AH40G
Organisme : NASA | Kennedy Space Center (KSC, Inc.)
ID : 80NSSC18K1478
Organisme : NASA | Kennedy Space Center (KSC, Inc.)
ID : 80NSSC18K1478
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