Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 03 2021
09 03 2021
Historique:
received:
08
08
2020
accepted:
10
02
2021
entrez:
22
3
2021
pubmed:
23
3
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Metallothionein-3 has poorly characterized functions in neuroblastoma. Cisplatin-based chemotherapy is a major regimen to treat neuroblastoma, but its clinical efficacy is limited by chemoresistance. We investigated the impact of human metallothionein-3 (hMT3) up-regulation in neuroblastoma cells and the mechanisms underlying the cisplatin-resistance. We confirmed the cisplatin-metallothionein complex formation using mass spectrometry. Overexpression of hMT3 decreased the sensitivity of neuroblastoma UKF-NB-4 cells to cisplatin. We report, for the first time, cisplatin-sensitive human UKF-NB-4 cells remodelled into cisplatin-resistant cells via high and constitutive hMT3 expression in an in vivo model using chick chorioallantoic membrane assay. Comparative proteomic analysis demonstrated that several biological pathways related to apoptosis, transport, proteasome, and cellular stress were involved in cisplatin-resistance in hMT3 overexpressing UKF-NB-4 cells. Overall, our data confirmed that up-regulation of hMT3 positively correlated with increased cisplatin-chemoresistance in neuroblastoma, and a high level of hMT3 could be one of the causes of frequent tumour relapses.
Identifiants
pubmed: 33750814
doi: 10.1038/s41598-021-84185-x
pii: 10.1038/s41598-021-84185-x
pmc: PMC7943580
doi:
Substances chimiques
Metallothionein 3
0
Neoplasm Proteins
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5496Références
Cancer Med. 2014 Feb;3(1):25-35
pubmed: 24403123
Sci Rep. 2018 Mar 9;8(1):4306
pubmed: 29523854
Mol Cancer Ther. 2004 Sep;3(9):1137-46
pubmed: 15367708
Neurotoxicology. 2008 May;29(3):489-503
pubmed: 18313142
Cells. 2019 Mar 12;8(3):
pubmed: 30871063
PLoS One. 2015 May 01;10(5):e0124865
pubmed: 25933064
Biosens Bioelectron. 2018 Jun 1;107:62-68
pubmed: 29438908
PLoS One. 2016 Jan 11;11(1):e0146501
pubmed: 26751205
Cancers (Basel). 2019 Aug 16;11(8):
pubmed: 31426364
Breast Cancer Res Treat. 1994;32(1):67-71
pubmed: 7819588
Anal Chem. 2013 Mar 19;85(6):3229-37
pubmed: 23421923
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Eur Arch Otorhinolaryngol. 2012 Aug;269(8):1967-71
pubmed: 22134668
Br J Cancer. 1999 Oct;81(4):712-20
pubmed: 10574261
Int J Mol Sci. 2012;13(8):9959-70
pubmed: 22949841
Int J Oncol. 2010 Dec;37(6):1417-23
pubmed: 21042709
Oncol Rep. 2019 Jun;41(6):3535-3544
pubmed: 31002354
J Inorg Biochem. 2019 Feb;191:29-39
pubmed: 30458366
Nature. 2016 Jan 21;529(7586):298-306
pubmed: 26791720
Clin Cancer Res. 2003 Nov 15;9(15):5768-75
pubmed: 14654562
PLoS One. 2017 Dec 8;12(12):e0189305
pubmed: 29220390
Semin Nucl Med. 2007 Jul;37(4):286-302
pubmed: 17544628
J Neurooncol. 2004 Mar-Apr;67(1-2):65-73
pubmed: 15072449
Metallomics. 2018 May 23;10(5):713-721
pubmed: 29687824
Neoplasma. 2005;52(5):415-9
pubmed: 16151587
Curr Opin Genet Dev. 2019 Feb;54:17-24
pubmed: 30877988
Anticancer Res. 2013 Mar;33(3):965-74
pubmed: 23482768
Cancer Detect Prev. 2000;24(1):53-60
pubmed: 10757123
Ann Neurol. 2016 Jul;80(1):13-23
pubmed: 27043043
Cancer Res. 2019 Oct 15;79(20):5382-5393
pubmed: 31405846
J Proteome Res. 2019 Mar 1;18(3):1255-1263
pubmed: 30592607
Int J Mol Sci. 2017 Sep 15;18(9):
pubmed: 28914774
Oncotarget. 2017 Jul 26;8(38):64591-64599
pubmed: 28969096
Sci Rep. 2019 May 15;9(1):7407
pubmed: 31092851
Tumour Biol. 2014 Sep;35(9):8483-523
pubmed: 25104089
Toxicol Appl Pharmacol. 2015 Dec 15;289(3):381-8
pubmed: 26529669
Int J Mol Sci. 2018 Feb 16;19(2):
pubmed: 29462944
Environ Health Perspect. 2000 May;108(5):413-8
pubmed: 10811567
Ageing Res Rev. 2013 Jan;12(1):376-90
pubmed: 23123177
Biomed Res Int. 2014;2014:209845
pubmed: 24800215
FEBS J. 2010 Jul;277(14):2921-30
pubmed: 20561054
Cancer Cell. 2015 Aug 10;28(2):170-82
pubmed: 26267534
BMC Cancer. 2014 May 18;14:339
pubmed: 24884418
Autophagy. 2018;14(11):1943-1958
pubmed: 30112966
Anticancer Res. 2010 Jul;30(7):2577-81
pubmed: 20682985
Cancers (Basel). 2019 Aug 01;11(8):
pubmed: 31374919
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 15;1039:17-27
pubmed: 27825623
Oncotarget. 2017 Dec 16;9(4):4427-4439
pubmed: 29435113
Int J Mol Sci. 2019 Jul 23;20(14):
pubmed: 31340550
Ocul Oncol Pathol. 2015 Apr;1(3):133-40
pubmed: 27171889
Nat Rev Cancer. 2009 Apr;9(4):274-84
pubmed: 19308067
World J Gastroenterol. 2017 Mar 14;23(10):1796-1803
pubmed: 28348485
Drug Metab Rev. 2019 May;51(2):196-223
pubmed: 31203662
Curr Drug Targets. 2016;17(12):1438-51
pubmed: 26424389
Mol Med. 2019 Mar 29;25(1):11
pubmed: 30925862
Sci Rep. 2016 Nov 08;6:36268
pubmed: 27824082
Histochem Cell Biol. 2008 Dec;130(6):1119-30
pubmed: 19005674
Int J Oncol. 2015 Jul;47(1):343-52
pubmed: 25963435
Toxicol Lett. 1999 Apr 12;105(3):207-14
pubmed: 10355541
Int J Cancer. 2018 May 15;142(10):1977-1985
pubmed: 29250786
FEBS Lett. 2011 Jan 21;585(2):421-8
pubmed: 21187089
Metallomics. 2016 Jan;8(1):71-81
pubmed: 26583802
Toxicol Lett. 1997 Jul 21;92(2):149-60
pubmed: 9295238
BMC Cancer. 2015 Oct 21;15:759
pubmed: 26490252
Cancer Res. 2003 Aug 1;63(15):4331-7
pubmed: 12907600
Leukemia. 2002 Apr;16(4):433-43
pubmed: 11960320
J Biol Chem. 2003 Aug 29;278(35):33422-35
pubmed: 12816952
Stress. 2007 Nov;10(4):342-50
pubmed: 17853063
Oxid Med Cell Longev. 2013;2013:972913
pubmed: 23766865
Clin Exp Med. 2010 Sep;10(3):169-72
pubmed: 20033752
Mol Biol Cell. 2007 Jun;18(6):1965-78
pubmed: 17360971
Int J Mol Sci. 2018 Sep 21;19(10):
pubmed: 30248944
Nature. 2015 Dec 17;528(7582):418-21
pubmed: 26560027
J Cell Physiol. 2018 Jan;234(1):152-157
pubmed: 30078179
Prostate. 2002 Jul 1;52(2):89-97
pubmed: 12111700
Genes Cells. 2003 Jan;8(1):17-28
pubmed: 12558796
Protein Sci. 2020 Jan;29(1):28-35
pubmed: 31423653
Anticancer Res. 2009 Apr;29(4):1219-25
pubmed: 19414367
Sci Rep. 2019 Mar 25;9(1):5039
pubmed: 30911132
Int J Oncol. 2014 Mar;44(3):923-33
pubmed: 24366574
BMC Cancer. 2018 Jan 4;18(1):28
pubmed: 29301505
Biomed Pharmacother. 2018 May;101:129-136
pubmed: 29482058
Prostate. 1999 Nov 1;41(3):196-202
pubmed: 10517878
Br J Cancer. 2002 Aug 27;87(5):533-6
pubmed: 12189552
Anticancer Res. 2017 Sep;37(9):5179-5185
pubmed: 28870952
Int J Oncol. 2016 Dec;49(6):2487-2497
pubmed: 27840910
Sci Adv. 2015 Dec 18;1(11):e1500603
pubmed: 26824057
Curr Drug Targets. 2019;20(7):705-715
pubmed: 30556499